{"id":"W4415005831","doi":"10.1101/2025.10.08.674881","title":"Replicability of multivariate brain-behaviour associations depends on clinical profile","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mental Health Research Topics","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health; Fonds de recherche du Québec – Nature et technologies; National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Health Canada; National Institutes of Health; Canada First Research Excellence Fund; Fondation Brain Canada; McGill University; Canadian Bee Research Fund; Government of Canada","keywords":"Multivariate statistics; Sample size determination; Multivariate analysis; Canonical correlation; Sample (material); Cohort; Biobank; Correlation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1506814,0.001178074,0.001608685,0.001798149,0.001713019,0.003661431,0.001850949,0.00103429,0.003280459],"category_scores_gemma":[0.2752683,0.0009887862,0.001901526,0.001675244,0.004976616,0.003063458,0.003014366,0.002789892,0.00110601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005550938,"about_ca_system_score_gemma":0.001104917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002575951,"about_ca_topic_score_gemma":0.002831612,"domain_scores_codex":[0.9390275,0.03983464,0.004061044,0.0110253,0.004873933,0.001177608],"domain_scores_gemma":[0.7832612,0.1246266,0.00763876,0.07442588,0.008639804,0.001407662],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002571043,0.0004857903,0.7985034,0.001208034,0.009973678,0.000958113,0.006646108,0.007778206,0.04257661,0.0116268,0.0105266,0.1071457],"study_design_scores_gemma":[0.0005684578,0.001659478,0.879843,0.0004226614,0.002231622,0.001164812,0.001465783,0.02444347,0.0154056,0.05412262,0.01849287,0.0001796521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5740386,0.002861937,0.4028826,0.00353462,0.001395266,0.001576112,0.003437866,0.001432209,0.008840748],"genre_scores_gemma":[0.9530764,0.0002552374,0.04108513,0.0007708893,0.0001584438,0.001669736,0.001545773,0.0004467743,0.0009914773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8493186,"threshold_uncertainty_score":0.7968888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09606204062878673,"score_gpt":0.4338055461769584,"score_spread":0.3377435055481717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}