{"id":"W4415007145","doi":"10.1101/2025.10.07.25337434","title":"Head-to-head comparison of plasma p-tau217 immunoassays for incipient Alzheimer’s disease in community cohorts","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Disease; Cohort; Epidemiology; Amyloid (mycology); Incidence (geometry)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002724799,0.0008383032,0.0006316449,0.00102274,0.0009841927,0.001091646,0.0007738129,0.0008508312,0.001941857],"category_scores_gemma":[0.005271778,0.0004889649,0.0005853449,0.000643115,0.0004717593,0.0004948655,0.0008842461,0.0004886632,0.0007231447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003854087,"about_ca_system_score_gemma":0.0003869704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00424501,"about_ca_topic_score_gemma":0.007374861,"domain_scores_codex":[0.9979439,0.0007359867,0.0001128569,0.0007635962,0.000287599,0.0001559671],"domain_scores_gemma":[0.9961736,0.0007727455,0.0007972028,0.0005618132,0.001341758,0.0003529044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007031318,0.0002246621,0.9828222,0.0000867454,0.001382173,0.0001139589,0.0003804097,0.0001030805,0.002710397,0.0000481703,0.0004341081,0.004662727],"study_design_scores_gemma":[0.0001659031,0.0009976663,0.995989,0.00001745856,0.0004413257,0.0002106141,0.0003173728,0.0003630631,0.0009006453,0.00008524922,0.0004950394,0.0000166846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975622,0.0005073876,0.0004646083,0.00002124821,0.00001781557,0.00008423626,0.0006295454,0.00001695031,0.000696042],"genre_scores_gemma":[0.9984175,0.00009961736,0.0003097937,0.00003363226,0.00001958666,0.00009519753,0.0007171995,0.000008921646,0.0002985298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00424501,"threshold_uncertainty_score":0.01441026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08904847553567766,"score_gpt":0.4295990688101494,"score_spread":0.3405505932744718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}