{"id":"W4415007154","doi":"10.1101/2025.10.08.681005","title":"Senolytic Therapy as a Preventive Strategy for Low Back Pain","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biochemical effects in animals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Degeneration (medical); Low back pain; Inflammation; Intervertebral disc; Senescence; Back pain; Intervention (counseling)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001476223,0.0008023149,0.001172853,0.0002652254,0.00009824648,0.0001392555,0.0005181668,0.0012042,0.0002340556],"category_scores_gemma":[0.001317892,0.0007832305,0.0004917939,0.0004727662,0.0001964569,0.00006403651,0.0003268657,0.001151862,0.00013341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004364878,"about_ca_system_score_gemma":0.001904679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003088546,"about_ca_topic_score_gemma":5.158715e-7,"domain_scores_codex":[0.9963841,0.0003060457,0.0006990199,0.001419233,0.0004239532,0.0007676092],"domain_scores_gemma":[0.9963947,0.0005436181,0.0003958751,0.001529814,0.0007471272,0.0003888599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008682556,0.0007909573,0.0006395839,0.00741562,0.001132222,0.0000682496,0.00001243027,0.00002049211,0.9822515,0.0009945342,0.005744834,0.00006133039],"study_design_scores_gemma":[0.003448105,0.0009697797,0.00517243,0.005132571,0.0003184062,4.118985e-8,0.000004930566,0.001478715,0.9739293,0.00003925459,0.008439821,0.001066574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589089,0.009097317,0.01043312,0.001687326,0.001893817,0.01515947,0.00113657,0.001178508,0.0005049343],"genre_scores_gemma":[0.9854136,0.0005639852,0.009357356,0.002215234,0.0008104981,0.001127446,0.000002257482,0.0001815527,0.0003280915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02650464,"threshold_uncertainty_score":0.9994619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02030518898050024,"score_gpt":0.277825766667339,"score_spread":0.2575205776868388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}