{"id":"W4415008679","doi":"10.3390/cancers17193272","title":"Immune Checkpoint Inhibitors in Merkel Cell Carcinoma of the Skin: A 2025 Comprehensive Review","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta; University of Saskatchewan","funders":"","keywords":"Avelumab; Merkel cell carcinoma; Pembrolizumab; Adjuvant; Clinical trial; Immunotherapy; Merkel cell; Merkel cell polyomavirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001764038,0.001065761,0.003657175,0.006216547,0.0002981306,0.001359089,0.000986919,0.001384847,0.00481159],"category_scores_gemma":[0.003329153,0.0004428829,0.002995857,0.005929672,0.0002482119,0.00125193,0.0006092512,0.0007155696,0.0005266808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001091465,"about_ca_system_score_gemma":0.003690077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002612449,"about_ca_topic_score_gemma":0.006015898,"domain_scores_codex":[0.9991786,0.0001766076,0.0002781839,0.0000984275,0.0002221775,0.00004604804],"domain_scores_gemma":[0.9978498,0.001218764,0.0005088632,0.00002769106,0.0003354325,0.00005936572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000340702,0.00007012772,0.0004707587,0.5343607,0.002792101,0.0002340292,0.0001040217,0.0002496846,0.0006510916,0.0004787578,0.01319066,0.4470572],"study_design_scores_gemma":[0.0004336199,0.0009020463,0.007979627,0.6575423,0.0288422,0.002386758,0.0002928634,0.0002880538,0.0005575501,0.0007539797,0.2999424,0.00007862187],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009734817,0.9996056,0.00001171356,0.00009149462,0.00005399388,0.00001082355,0.00002317526,0.000001536354,0.0001043221],"genre_scores_gemma":[0.0008320065,0.9987637,0.00007379282,0.0001382206,0.00007049235,0.00001669015,0.00003865643,6.403128e-7,0.00006593219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006216547,"threshold_uncertainty_score":0.01609635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722620677572767,"score_gpt":0.3191953348906345,"score_spread":0.2919691281149068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}