{"id":"W4415009717","doi":"10.1093/gerona/glaf196","title":"A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity","year":2025,"lang":"en","type":"article","venue":"The Journals of Gerontology Series A","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Health and Medical Research Council; University of Adelaide; World Health Organization","keywords":"Genetic architecture; Genetic variants; Association (psychology); Genetic association; Human genetics; Foundation (evidence); Genomics; Genetic variation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001259729,0.0008462807,0.0006185778,0.001090472,0.0008290534,0.0008588364,0.0007965496,0.001239546,0.00441049],"category_scores_gemma":[0.003580282,0.000321477,0.001250053,0.002463274,0.0006090599,0.0002475456,0.0006519815,0.001058376,0.0004304537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391152,"about_ca_system_score_gemma":0.0009049433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01205972,"about_ca_topic_score_gemma":0.01786417,"domain_scores_codex":[0.9989921,0.0001483386,0.0001021441,0.0004541542,0.0001446903,0.0001585282],"domain_scores_gemma":[0.9975719,0.001104155,0.0006230574,0.0001820578,0.0002135311,0.0003053446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001922486,0.0001496833,0.9611356,0.0003455005,0.002600909,0.004209555,0.0004835378,0.0006214321,0.01086262,0.0005689692,0.001882287,0.01521744],"study_design_scores_gemma":[0.0001638504,0.0001497059,0.9934345,0.00006242275,0.001007585,0.001706242,0.0001338209,0.0007065557,0.0006115928,0.0004075202,0.001593537,0.00002255677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913276,0.002415675,0.001832245,0.0003991268,0.0000644759,0.00003729245,0.002507454,0.00006918759,0.001346815],"genre_scores_gemma":[0.9962787,0.0003677691,0.00136612,0.0001305587,0.0000344328,0.00002765157,0.001230461,0.00001350177,0.0005508364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01205972,"threshold_uncertainty_score":0.02397907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03068465042182039,"score_gpt":0.2809919997104823,"score_spread":0.2503073492886619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}