{"id":"W4415012406","doi":"10.1016/j.immuni.2025.09.014","title":"Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; University of Saskatchewan; Hospital for Sick Children; Government of Saskatchewan; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Canada Research Chairs; Federation of European Microbiological Societies; Japan Agency for Medical Research and Development; Canada Foundation for Innovation; National Research Council Canada; KWF Kankerbestrijding; National Research Council; Oncode Institute; Brookhaven National Laboratory; U.S. Department of Energy","keywords":"Plasmodium falciparum; Epitope; Antibody; Malaria; Endogeny; Protein structure; Peptide sequence; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759085,0.0002300169,0.0004472357,0.00007693551,0.0001745133,0.00001404857,0.000381665,0.0002331636,0.00009185545],"category_scores_gemma":[0.00006982376,0.0001901262,0.0001234114,0.0001601713,0.0001049863,0.000006564338,0.0001277238,0.0001658861,4.11495e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001169239,"about_ca_system_score_gemma":0.0001225632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000224843,"about_ca_topic_score_gemma":0.00005211067,"domain_scores_codex":[0.9987116,0.0002986036,0.0003031261,0.0002619636,0.0001817446,0.000242912],"domain_scores_gemma":[0.9988446,0.00005757626,0.000240824,0.0006321173,0.0001740719,0.00005077147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004350136,0.0001042706,0.0003021801,0.0002505752,0.0001586396,0.000002363576,0.0001454488,0.00003010272,0.9896939,0.001092316,0.00002088074,0.007764264],"study_design_scores_gemma":[0.0005099092,0.0003554649,0.005221341,0.0001533242,0.00007357543,0.00001472645,0.0002044856,0.00001271765,0.9898045,0.00319258,0.0002752888,0.0001820738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596971,0.0004782043,0.03848615,0.00006689248,0.00007016909,0.0003639521,0.0001177572,0.00001404752,0.0007057328],"genre_scores_gemma":[0.9907408,0.00007340428,0.008912113,0.00005383099,0.00001891362,0.000006512483,0.00004787003,0.00002038282,0.0001261191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03104375,"threshold_uncertainty_score":0.7753121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808103179301442,"score_gpt":0.2519091787699985,"score_spread":0.2338281469769841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}