{"id":"W4415022334","doi":"10.1113/jp289770","title":"Special issue: The giant impact of synapses on brain function and disease","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Mental Health Research Canada; Canada Research Chairs","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Action for A-T; University of Pennsylvania Health System; National Institute on Deafness and Other Communication Disorders; University of Pennsylvania","keywords":"Synapse; Synaptic plasticity; Endocytosis; Long-term potentiation; Amyotrophic lateral sclerosis; Disease; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00245905,0.002872375,0.00279554,0.001939565,0.002388638,0.007746365,0.002948925,0.008589671,0.0523639],"category_scores_gemma":[0.005382124,0.0008614156,0.001846291,0.0009172789,0.001593076,0.003124029,0.002298311,0.006611756,0.01927198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002646217,"about_ca_system_score_gemma":0.002561969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007272132,"about_ca_topic_score_gemma":0.00181668,"domain_scores_codex":[0.9977643,0.0002227006,0.0002477305,0.0003897276,0.0009882925,0.0003871727],"domain_scores_gemma":[0.9933415,0.001123711,0.0005889508,0.000222567,0.002101715,0.002621518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001204495,0.00002986416,0.0001684713,0.0003997523,0.00002277386,0.0002149746,0.00002573605,0.00004928119,0.0004385392,0.0006326155,0.9824411,0.01545643],"study_design_scores_gemma":[0.00005880873,0.0001045377,0.001369373,0.0003663723,0.00005048329,0.0007047226,0.00008535235,0.0002093193,0.0004498053,0.001402289,0.9951712,0.00002766866],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0006267411,0.01477032,0.0002615844,0.03137949,0.9412956,0.00008056227,0.0003307825,0.000240576,0.01101434],"genre_scores_gemma":[0.001736496,0.01061825,0.0001212284,0.008576206,0.9588697,0.00005402841,0.0001805256,0.00007051689,0.01977302],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.0523639,"threshold_uncertainty_score":0.1751747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007618088419917794,"score_gpt":0.2679682816052239,"score_spread":0.2603501931853061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}