{"id":"W4415023189","doi":"10.1016/s1470-2045(25)00400-0","title":"Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis","year":2025,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Medical Research Council; Fru Berta Kamprads Stiftelse; Lunds Universitet; Cancerfonden; Vetenskapsrådet; Sunway University; Cancer Research UK; National Institute for Health and Care Research; Heart of England NHS Foundation Trust; Dr. Josef Steiner Krebsstiftung; Department of Health and Social Care; Mats Paulssons Stiftelse; Wellcome Trust; NIHR Cambridge Biomedical Research Centre; Breast Cancer Research Foundation","keywords":"Breast cancer; Linked data; Cancer; Population; Retrospective cohort study; Epidemiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002354812,0.0003669768,0.0006317277,0.00245748,0.0004061698,0.001175869,0.0006261175,0.0005436158,0.001106398],"category_scores_gemma":[0.01321398,0.0004961208,0.000657884,0.004868769,0.0005676026,0.0005545407,0.00170955,0.0005065894,0.0003151516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007543043,"about_ca_system_score_gemma":0.0005634036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01086444,"about_ca_topic_score_gemma":0.009234395,"domain_scores_codex":[0.996393,0.0009294859,0.0007124285,0.000974932,0.0007022091,0.0002878768],"domain_scores_gemma":[0.9881684,0.002595604,0.005377001,0.002119509,0.001228332,0.0005111798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009838783,0.000004491909,0.9978505,0.00003905268,0.0001182326,0.0001739605,0.0001201757,0.0000789062,0.0002035071,0.00002016958,0.0001953607,0.001097347],"study_design_scores_gemma":[0.000005787393,0.00003831749,0.9980938,0.00002852986,0.00007850857,0.0006791455,0.0001327667,0.0001989441,0.0001029129,0.00002091254,0.0006131214,0.000007359456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933289,0.001056469,0.0003327515,0.00008397477,0.000007445384,0.00002157257,0.004771246,0.000008706363,0.0003888527],"genre_scores_gemma":[0.9939283,0.0004314805,0.0002674301,0.00006741584,0.000009130217,0.00003489668,0.005126986,0.00000718388,0.0001271481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01086444,"threshold_uncertainty_score":0.02160239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02568736857681929,"score_gpt":0.3671962507591854,"score_spread":0.3415088821823661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}