{"id":"W4415024770","doi":"10.1038/s44321-025-00316-1","title":"Glia inflammation and cell death pathways drive disease progression in preclinical and early AD","year":2025,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Olav Thon Stiftelsen; Kirsten og Freddy Johansens Fond; UK Dementia Research Institute; Cure Alzheimer's Fund; Vetenskapsrådet; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft; European Partnership on Metrology; Corona-Stiftung; Canadian Institutes of Health Research; Weston Brain Institute; Stiftelsen för Gamla Tjänarinnor; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; Alzheimer's Association","keywords":"Neuroinflammation; Neurodegeneration; Inflammation; Microglia; Programmed cell death; Disease; Immune system; Cerebrospinal fluid; Traumatic brain injury","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235421,0.0001541613,0.0001879616,0.0002077954,0.00009203799,0.0000368906,0.00009489465,0.00005917535,0.00001546179],"category_scores_gemma":[0.0009643593,0.0001298041,0.00002175333,0.0002472727,0.0001036742,0.0001266266,0.00008892262,0.0001846997,0.000005022061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000125899,"about_ca_system_score_gemma":0.00004843065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001913516,"about_ca_topic_score_gemma":0.000001934362,"domain_scores_codex":[0.9984249,0.0002595676,0.000370438,0.0004905931,0.0002868344,0.000167643],"domain_scores_gemma":[0.9993221,0.0001460512,0.00009951677,0.0002270739,0.000032098,0.0001731893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006995161,0.00002992604,0.001052501,0.00005186197,8.281625e-7,0.0001581333,0.0002038459,0.00001149967,0.9807081,0.01277424,0.00003048724,0.004908646],"study_design_scores_gemma":[0.001948409,0.0002254797,0.02560137,0.0002264091,0.00002378769,0.000004590957,0.00001816689,0.00431493,0.961229,0.005568565,0.0006965965,0.0001426745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924659,0.0003233335,0.002013079,0.003385955,0.000193082,0.0005559587,0.000002022212,0.00006819075,0.0009925533],"genre_scores_gemma":[0.9979989,0.0002380701,0.0002531144,0.001186442,0.00003328115,0.00004217274,0.000003977857,0.00001305206,0.000231016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02454887,"threshold_uncertainty_score":0.5293258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712751498259183,"score_gpt":0.3070241017051191,"score_spread":0.2798965867225273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}