{"id":"W4415026722","doi":"10.1038/s41467-025-63829-w","title":"Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Montreal General Hospital; Montreal Neurological Institute and Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Janssen Pharmaceuticals; Canadian Institutes of Health Research; Sanofi Genzyme; National Health and Medical Research Council; Allergan; Genentech; Parkinson Vereniging; H. Lundbeck A/S; Servier; Agentura Pro Zdravotnický Výzkum České Republiky; Avid Radiopharmaceuticals; Ministerstvo Školství, Mládeže a Tělovýchovy; Parkinson's UK; European Commission; AbbVie; Denali Therapeutics; Neurocrine Biosciences; EU Joint Programme – Neurodegenerative Disease Research; Parkinsonforeningen; Pfizer; Biogen; Celgene; National Institute for Health and Care Research; Jascha Fonden; Medical Research Council; Teva Pharmaceutical Industries; Meso Scale Diagnostics; Sanofi; Parkinson Canada; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Roche; GlaxoSmithKline; Alzheimer Society; Lundbeckfonden; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Atrophy; Synucleinopathies; Gene expression; Sleep (system call); Neuroimaging; Sex characteristics; Neuroprotection; Transcriptome; Receptor expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906197,0.0001610962,0.000239505,0.0004889789,0.00009940749,0.0002875364,0.0001232482,0.0001555381,0.001562127],"category_scores_gemma":[0.0004341843,0.0001132065,0.0002142294,0.0003307053,0.0001835107,0.0001016134,0.0001855669,0.0001602335,0.0001956316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007353494,"about_ca_system_score_gemma":0.00005526718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005769465,"about_ca_topic_score_gemma":0.000987352,"domain_scores_codex":[0.9999088,0.00001878855,0.000008968214,0.00003713799,0.00001335384,0.00001294798],"domain_scores_gemma":[0.999714,0.00004813258,0.0001594851,0.00003173206,0.00001774071,0.0000289843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001638586,0.00004777098,0.9231434,0.00005172481,0.0003017486,0.0008073859,0.0002780474,0.000101652,0.06300224,0.00008551972,0.0003480821,0.01019386],"study_design_scores_gemma":[0.000004719833,0.00003674595,0.9983417,0.000003225007,0.0000185883,0.0006299448,0.00004547323,0.00004152149,0.0007086853,0.00003977427,0.0001275526,0.000001955379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99889,0.0003987502,0.00009348989,0.00002677121,0.000002689705,0.000001707429,0.0003802505,0.000003703649,0.0002026315],"genre_scores_gemma":[0.9988971,0.0002118625,0.00009924664,0.0000300238,0.000005005819,0.000004347543,0.0004067789,0.000005669794,0.0003399199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562127,"threshold_uncertainty_score":0.005225778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116861172363225,"score_gpt":0.2889471266314845,"score_spread":0.277261009395162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}