{"id":"W4415027635","doi":"10.1523/jneurosci.0378-25.2025","title":"Epigenetic Repression of miR-216a-3p via H3K27me3 Drives STIM1-Mediated Neuronal Excitability in Neuropathic Pain","year":2025,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Epigenetics; Histone; Epigenetic regulation of neurogenesis; Chromatin; Neuropathic pain; Histone deacetylase; DNA methylation; Regulation of gene expression; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130776,0.000297731,0.0004697156,0.0003273358,0.0004102374,0.0006774089,0.0003265357,0.0003637789,0.00401265],"category_scores_gemma":[0.0002812926,0.0002965189,0.0006330695,0.0002286337,0.0004181693,0.0003710344,0.0005972002,0.001143763,0.001293807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005394614,"about_ca_system_score_gemma":0.0004933681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001650903,"about_ca_topic_score_gemma":0.004038436,"domain_scores_codex":[0.999739,0.0000217583,0.00001924695,0.00007838506,0.00007811588,0.00006366252],"domain_scores_gemma":[0.9999148,0.000009050113,0.00002799657,0.00001023263,0.0000165364,0.00002139414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005184009,0.00006145384,0.001982725,0.0003552601,0.0000457655,0.0001821425,0.0001556059,0.0002536714,0.9831525,0.001045978,0.001241273,0.01100529],"study_design_scores_gemma":[0.0001650931,0.0006072107,0.06540245,0.0001394438,0.0002752068,0.001180509,0.0004690602,0.00711476,0.8775895,0.001676951,0.04530038,0.0000794598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420381,0.016806,0.01552772,0.0009255205,0.0006161557,0.0001269093,0.004620051,0.00136203,0.01797745],"genre_scores_gemma":[0.9861718,0.002865428,0.003080737,0.0003883782,0.00002892984,0.0001384196,0.001584649,0.0001618672,0.005579831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00401265,"threshold_uncertainty_score":0.01342362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903043892468048,"score_gpt":0.2975718769324753,"score_spread":0.2785414380077949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}