{"id":"W4415027969","doi":"10.21203/rs.3.rs-7593592/v1","title":"VEXAS syndrome, immunodeficiency, and risk of infection","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pneumonia; Mononucleosis; Immunodeficiency Syndrome; Retrospective cohort study; Immunodeficiency; Bone marrow; Tocilizumab; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004005834,0.0003112223,0.0002779507,0.001100685,0.000268457,0.0006975563,0.0002530813,0.0006398125,0.004836051],"category_scores_gemma":[0.004047824,0.00009874351,0.000179878,0.0008320989,0.0002916341,0.0003238923,0.0003039397,0.0004920153,0.000199066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391026,"about_ca_system_score_gemma":0.0002436843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203544,"about_ca_topic_score_gemma":0.0005243431,"domain_scores_codex":[0.999692,0.00014743,0.00002863438,0.00003211735,0.00005005564,0.00004989436],"domain_scores_gemma":[0.9984609,0.0007591536,0.0003696864,0.00009947483,0.00006070727,0.0002501241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00104352,0.00009834018,0.9829369,0.00004575773,0.0001318087,0.003439876,0.0001696397,0.0001601343,0.001425236,0.001087304,0.0004240674,0.009037276],"study_design_scores_gemma":[0.00006531758,0.0003363619,0.980608,0.00005961748,0.00011831,0.0134933,0.000502495,0.0009269031,0.0003169745,0.00246816,0.00109027,0.00001432728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992949,0.002708546,0.0002860466,0.0004962313,0.00003122808,0.000005287745,0.0002651649,0.000014694,0.003243777],"genre_scores_gemma":[0.998702,0.000422432,0.0001535415,0.00002698233,0.00006891138,0.000002874104,0.00008167943,0.00000214371,0.0005392951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004836051,"threshold_uncertainty_score":0.01617819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213061403199573,"score_gpt":0.3863408274475416,"score_spread":0.3542102134155459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}