{"id":"W4415030059","doi":"10.1016/j.jpet.2025.103747","title":"Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility","year":2025,"lang":"en","type":"review","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Office of Extramural Research, National Institutes of Health; Hevolution Foundation; National Eye Institute; National Institute on Aging; University of Oklahoma Health Sciences Center; University of Oklahoma; Institute of Aging; Presbyterian Health Foundation; National Institutes of Health; National Institute of General Medical Sciences; Kansas IDeA Network of Biomedical Research Excellence","keywords":"Central nervous system; Endothelium; Transdifferentiation; Endothelial dysfunction; Function (biology); Neurovascular bundle; Blood–brain barrier; Neuroplasticity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007604187,0.0004452096,0.001614112,0.0003945652,0.0001212932,0.00003821931,0.0003258874,0.0003485546,0.0001299694],"category_scores_gemma":[0.000004966554,0.0002972342,0.0008964993,0.0004386224,0.0001353416,0.000043956,0.0000507545,0.0008217836,0.000007969816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359907,"about_ca_system_score_gemma":0.0003848127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000202654,"about_ca_topic_score_gemma":0.000001732512,"domain_scores_codex":[0.996858,0.0009370503,0.001019752,0.0003226309,0.0004125399,0.0004500364],"domain_scores_gemma":[0.9991825,0.0001143796,0.0002404042,0.0002111044,0.00006927107,0.0001823496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0034841,0.0058489,0.00005117879,0.01966584,0.01643077,0.00254461,0.02421474,0.001033631,0.01900837,0.0002657741,0.001808634,0.9056435],"study_design_scores_gemma":[0.01321145,0.003905121,0.0005538999,0.006831537,0.01774926,0.004417525,0.006324581,0.0002463843,0.001802442,0.0001178483,0.9438302,0.001009759],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005886417,0.9890398,0.0005635684,0.0008143851,0.00147258,0.002022922,0.00002313349,0.00001514504,0.0001620221],"genre_scores_gemma":[0.139376,0.854686,0.0002329768,0.005153913,0.0003358367,0.0000786307,0.00003208732,0.00004480897,0.00005971971],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9420215,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898529248295844,"score_gpt":0.3444948224976877,"score_spread":0.3255095300147293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}