{"id":"W4415030761","doi":"10.1128/spectrum.00935-25","title":"Reproducible 3D bioprinting of <i>Streptococcus mutans</i> to create model oral biofilms","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health; National Science Foundation of Sri Lanka; University of Rochester; University of Oregon; Arnold and Mabel Beckman Foundation","keywords":"Biofilm; Streptococcus mutans; Virulence; Homogeneous; Virulence factor; Agar","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003196525,0.0003802541,0.0001864276,0.0002344776,0.0001735685,0.0004237224,0.0002662915,0.000430364,0.00065281],"category_scores_gemma":[0.0002609029,0.0002365525,0.0003256599,0.0001485903,0.0002631751,0.0001975868,0.0003302513,0.0004288666,0.0002951774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208126,"about_ca_system_score_gemma":0.0001900567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005353527,"about_ca_topic_score_gemma":0.0009223995,"domain_scores_codex":[0.9997926,0.0000227965,0.00001708813,0.00004185727,0.00009503681,0.00003067011],"domain_scores_gemma":[0.9997863,0.00004998699,0.00007290397,0.00003850485,0.00002866397,0.0000235375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000570129,0.00001005465,0.00006958196,0.00002178985,0.000001744987,0.0000241507,0.00001435279,0.0003298634,0.9986026,0.00007251481,0.00002831111,0.0008192526],"study_design_scores_gemma":[0.00000215475,0.00004771743,0.0007793439,0.000005299607,0.000003665655,0.00005368495,0.00001416572,0.002745761,0.9950558,0.00004260273,0.001244139,0.000005719016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551411,0.001024957,0.03898253,0.0001074805,0.00008868336,0.0001217488,0.000503131,0.0005079887,0.003522435],"genre_scores_gemma":[0.94669,0.0005704181,0.05024864,0.0000549779,0.000008978996,0.0001616035,0.0002370993,0.00009871223,0.001929545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00065281,"threshold_uncertainty_score":0.002327621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007726692324718129,"score_gpt":0.2435122570580052,"score_spread":0.2357855647332871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}