{"id":"W4415035241","doi":"10.1126/sciimmunol.adv5085","title":"Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Inhibitory postsynaptic potential; Phagocytosis; Immune system; CD47; Blockade; Function (biology); Immune checkpoint; Receptor; Macrophage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419417,0.0003027996,0.0002643737,0.0001094238,0.00008671248,0.0002759342,0.000172945,0.0001703944,0.0006226386],"category_scores_gemma":[0.0001255484,0.0001100112,0.0001771996,0.00005374632,0.0001677245,0.0001906564,0.0002304722,0.0006998532,0.0002578903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001943354,"about_ca_system_score_gemma":0.0001420541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266914,"about_ca_topic_score_gemma":0.0001741414,"domain_scores_codex":[0.9998105,0.0000343932,0.00001048505,0.00002352687,0.00005674971,0.0000643356],"domain_scores_gemma":[0.9999044,0.00001288991,0.00003220442,0.00001282548,0.00001454502,0.00002318978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009545802,0.00001045328,0.0001546767,0.00001476669,0.000003634943,0.00002996507,0.000004671145,0.00007216285,0.9984264,0.0002077015,0.00002524455,0.0009548216],"study_design_scores_gemma":[0.000007976822,0.0001449857,0.00101035,0.000003858841,0.000008808477,0.0001954195,0.00001169851,0.001086934,0.995966,0.00006279303,0.001499907,0.000001386638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991028,0.001688338,0.004754458,0.00008479378,0.00002626225,0.00001644166,0.00003467665,0.00007045114,0.002296604],"genre_scores_gemma":[0.9979016,0.000427791,0.0007607364,0.00004612637,0.000005983646,0.00000862955,0.00005172676,0.000008725604,0.0007887239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006226386,"threshold_uncertainty_score":0.002082884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170421649583243,"score_gpt":0.2860889897215536,"score_spread":0.2743847732257212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}