{"id":"W4415035241","doi":"10.1126/sciimmunol.adv5085","title":"Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Inhibitory postsynaptic potential; Phagocytosis; Immune system; CD47; Blockade; Function (biology); Immune checkpoint; Receptor; Macrophage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007923158,0.000188137,0.0004272012,0.0005466809,0.000379258,0.00003177362,0.0005611441,0.0002471179,0.0002029923],"category_scores_gemma":[0.0004970224,0.000172144,0.0001169404,0.0008019872,0.00241903,0.0005767683,0.000274719,0.0003399971,0.00007224333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132325,"about_ca_system_score_gemma":0.0003608488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002808005,"about_ca_topic_score_gemma":0.00000994172,"domain_scores_codex":[0.9981598,0.0002395133,0.000617097,0.0004484172,0.00007440865,0.0004607689],"domain_scores_gemma":[0.9985445,0.0001792369,0.0004241977,0.0005698169,0.0002692609,0.00001300597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005148444,0.000145674,0.001189518,0.00001218088,0.00009409783,4.785246e-7,0.0002335192,0.000003007886,0.9871851,0.001023976,0.0008263628,0.008771251],"study_design_scores_gemma":[0.0008648448,0.0001694828,0.09387337,0.0001113787,0.00002301887,0.00001808869,0.0008736628,0.000009982254,0.8936496,0.0002959557,0.009973953,0.0001366487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799972,0.01429761,0.0003867237,0.0009286291,0.002786522,0.0002114759,0.00001570342,0.00005878734,0.001317409],"genre_scores_gemma":[0.995341,0.0003171458,0.00003547606,0.00009569546,0.000009664942,0.00002256188,0.0000224386,0.000008325164,0.004147687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09353547,"threshold_uncertainty_score":0.8913016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170421649583243,"score_gpt":0.2860889897215536,"score_spread":0.2743847732257212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}