{"id":"W4415043591","doi":"10.1101/2025.10.08.681270","title":"HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Circadian rhythm; Hypothalamus; Transcriptome; Disease; Human brain; Receptor; Microglia; Cell type","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002312618,0.0002188301,0.0003043103,0.0007055727,0.0002097623,0.000452775,0.0002287419,0.0002014633,0.001585799],"category_scores_gemma":[0.0002477475,0.0002103343,0.000286037,0.0004850763,0.0002001476,0.0001827919,0.0005661398,0.0002416299,0.0003279918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058762,"about_ca_system_score_gemma":0.0002257532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002504159,"about_ca_topic_score_gemma":0.005563062,"domain_scores_codex":[0.9999193,0.00001033998,0.000004305377,0.00003173198,0.00002101757,0.00001332515],"domain_scores_gemma":[0.9999005,0.00001866296,0.00002144947,0.00002052857,0.00002231849,0.0000165545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008142826,0.00004599486,0.06512624,0.0005013203,0.0003049382,0.0004866207,0.0006596126,0.005620219,0.8422086,0.001183205,0.004301885,0.07874722],"study_design_scores_gemma":[0.00005231516,0.0002836201,0.8446853,0.0001153113,0.0002656489,0.003123962,0.0006720068,0.02995091,0.08613406,0.004101888,0.03049255,0.0001224327],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9067121,0.005136689,0.06056114,0.0002014423,0.0000841104,0.00007210072,0.02304548,0.001048537,0.003138417],"genre_scores_gemma":[0.9321598,0.001945917,0.05094469,0.0001662322,0.00005685367,0.0001691359,0.01222302,0.000283386,0.002050845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002504159,"threshold_uncertainty_score":0.005305052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181810770628345,"score_gpt":0.2621484990675694,"score_spread":0.230330391361286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}