{"id":"W4415045967","doi":"10.1021/acsomega.5c05271","title":"NMR Analysis and Assignment of a Biosynthesis Gene Cluster for Trichokonins VI and VIII, Antiplasmodial Large Peptaibols Produced by a <i>Trichoderma</i> sp. Fungus","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Food and Agriculture; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; U.S. Department of Agriculture","keywords":"Gene cluster; Biosynthesis; Circular dichroism; Gene; Amino acid; Fungus; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004379785,0.0002790294,0.0001648828,0.0004509513,0.0001628031,0.000230427,0.0001515889,0.0002003788,0.0008680811],"category_scores_gemma":[0.0001604652,0.0000883094,0.0003000028,0.0004666334,0.0001264559,0.0001241315,0.0001740564,0.0002650359,0.0004571908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999301,"about_ca_system_score_gemma":0.0002448049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032398,"about_ca_topic_score_gemma":0.0008896166,"domain_scores_codex":[0.9999282,0.000005179641,0.00000673469,0.00003034187,0.00001565516,0.00001391751],"domain_scores_gemma":[0.9998691,0.00001550015,0.00003463928,0.00001060177,0.00003354067,0.00003658288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005690396,0.000009016892,0.0005545827,0.00002416749,0.000002228496,0.00008338439,0.00002855608,0.00003219885,0.9980883,0.00002150508,0.00002367639,0.001075443],"study_design_scores_gemma":[0.00002417028,0.0004940677,0.130558,0.00004052921,0.00009958616,0.001764323,0.0006946482,0.002545709,0.8550124,0.0002159039,0.008522599,0.0000280629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884738,0.0004034998,0.004382372,0.0001033489,0.00001733184,0.00005225463,0.004947186,0.00006864675,0.001551526],"genre_scores_gemma":[0.9569951,0.0007395073,0.02018044,0.00009054495,0.00002187576,0.00007373084,0.01854952,0.00006867478,0.003280665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032398,"threshold_uncertainty_score":0.002903998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782631193590052,"score_gpt":0.25032231544151,"score_spread":0.2424960035056095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}