{"id":"W4415045967","doi":"10.1021/acsomega.5c05271","title":"NMR Analysis and Assignment of a Biosynthesis Gene Cluster for Trichokonins VI and VIII, Antiplasmodial Large Peptaibols Produced by a <i>Trichoderma</i> sp. Fungus","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Food and Agriculture; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; U.S. Department of Agriculture","keywords":"Gene cluster; Biosynthesis; Circular dichroism; Gene; Amino acid; Fungus; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005512059,0.0002792729,0.0008210891,0.0005329775,0.00014495,0.00004939894,0.0001158512,0.0001907488,0.00001165675],"category_scores_gemma":[0.0005458519,0.0002118504,0.0001871522,0.001133063,0.0000905721,0.00009920758,0.0001246315,0.0001423407,0.000001141674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000501473,"about_ca_system_score_gemma":0.00007324854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000480888,"about_ca_topic_score_gemma":0.00001743992,"domain_scores_codex":[0.9981549,0.00006566642,0.0004797713,0.0006786966,0.0002152403,0.0004056653],"domain_scores_gemma":[0.9988086,0.0002921028,0.0001811135,0.000409518,0.0001798566,0.0001288225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009803177,0.000396739,0.01512584,0.0003673262,0.001449439,0.000003722446,0.0001349496,9.785311e-7,0.9543721,0.00003738484,0.01796614,0.009165044],"study_design_scores_gemma":[0.00294979,0.0002455013,0.007830042,0.00008177507,0.002833049,0.000007828847,0.00005906166,0.000237724,0.9609256,0.00002378131,0.02455065,0.0002551894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877006,0.003584079,0.0008497793,0.005859558,0.00008204548,0.001297152,0.0004698837,0.00003540588,0.0001215392],"genre_scores_gemma":[0.9948254,0.0007205739,0.00142824,0.0009885477,0.0001003479,0.00001655188,0.00006616602,0.00002121957,0.001833008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008909855,"threshold_uncertainty_score":0.8639009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782631193590052,"score_gpt":0.25032231544151,"score_spread":0.2424960035056095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}