{"id":"W4415054184","doi":"10.1101/2025.10.09.681375","title":"Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; Université de Montréal; Cancer Prevention and Research Institute of Texas","keywords":"Zebrafish; Gastrulation; Sulfatase; Convergent extension; Morphogenesis; Mesoderm; Embryo; Morpholino; Effector","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007588045,0.0004272002,0.0001943021,0.0003178959,0.0001737571,0.0002467167,0.0001742138,0.0002853617,0.001158912],"category_scores_gemma":[0.000113667,0.0002807115,0.0002615183,0.00008594351,0.0002502054,0.0001951666,0.0003362364,0.0003636714,0.0003856961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006253991,"about_ca_system_score_gemma":0.0002748451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003103299,"about_ca_topic_score_gemma":0.005001286,"domain_scores_codex":[0.9999044,0.000005250743,0.000007184961,0.00002981277,0.00002966612,0.00002368498],"domain_scores_gemma":[0.9998814,0.00001071609,0.0000467856,0.000008589264,0.00001905401,0.00003333594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002692428,0.000001293877,0.0003406539,0.000006893894,8.513735e-7,0.0000225349,0.000006781152,0.00003049434,0.999121,0.00003243154,0.0000169315,0.0003931946],"study_design_scores_gemma":[0.000009450561,0.00007216968,0.03606643,0.00000637125,0.0000116864,0.0001255007,0.00003670068,0.001354735,0.9604055,0.00004326092,0.001854632,0.00001350904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928395,0.0009528298,0.003321528,0.00005146559,0.00002025003,0.00001675208,0.0006020152,0.0001443827,0.002051318],"genre_scores_gemma":[0.9915096,0.0003735122,0.002539764,0.00005155601,0.000005766781,0.00002356812,0.0004134172,0.00004794287,0.00503494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003103299,"threshold_uncertainty_score":0.006170452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915464223370975,"score_gpt":0.2579745026389384,"score_spread":0.2388198604052287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}