{"id":"W4415063946","doi":"10.71000/79d1ah89","title":"NARRATIVE REVIEW ON THE IMPACT OF GENE MUTATIONS IN DISEASE SUSCEPTIBILITY, PROGRESSION, AND TARGETED THERAPEUTIC APPROACHES: A NARRATIVE REVIEW.NARRATIVE REVIEW ON THE IMPACT OF GENE MUTATIONS IN DISEASE SUSCEPTIBILITY, PROGRESSION, AND TARGETED THERAPEUTIC APPROACHES","year":2025,"lang":"en","type":"article","venue":"Insights-Journal of Health and Rehabilitation","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Disease; Targeted therapy; Precision medicine; Gene; Gene mutation; Genome editing; Mutation; Genetic enhancement; Narrative review","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296564,0.0007817228,0.001061358,0.002318456,0.0003561815,0.001745964,0.0007571728,0.001279691,0.01005657],"category_scores_gemma":[0.005705783,0.0002355366,0.001268537,0.001882119,0.0004342609,0.001660831,0.0008276453,0.001598245,0.001740403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009706768,"about_ca_system_score_gemma":0.003178233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264727,"about_ca_topic_score_gemma":0.002499633,"domain_scores_codex":[0.999371,0.0001751645,0.0001437416,0.00008577764,0.0001778025,0.00004657453],"domain_scores_gemma":[0.9971011,0.001953154,0.000429109,0.00004002466,0.0004031333,0.00007332863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002228379,0.00004425242,0.0004441518,0.1526507,0.0004690493,0.0009966275,0.0004492373,0.0006562165,0.001100362,0.0110384,0.1795318,0.6523963],"study_design_scores_gemma":[0.0000239737,0.00008314181,0.0007052639,0.05818667,0.0006012939,0.002673721,0.0001948328,0.00007494866,0.0002400423,0.00264104,0.934549,0.00002599262],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001605697,0.9944043,0.0002149724,0.002233465,0.0006283653,0.00002700088,0.0001733038,0.000009798639,0.002148129],"genre_scores_gemma":[0.001482394,0.9950144,0.0003522189,0.001570009,0.0005592278,0.00003864557,0.0001755203,0.000004837581,0.0008027355],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01005657,"threshold_uncertainty_score":0.03364253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04931508944321501,"score_gpt":0.3887767550615956,"score_spread":0.3394616656183806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}