{"id":"W4415073375","doi":"10.1002/hbm.70357","title":"Automated <scp>MRI</scp> Segmentation of Brainstem Nuclei Critical to Consciousness","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Blueprint for Neuroscience Research; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; McDonnell Center for Systems Neuroscience; Genentech; National Institutes of Health; Eisai Canada; National Institute of Neurological Disorders and Stroke; Takeda Pharmaceutical Company; Rappaport Foundation; IXICO; Servier; Eisai; Northern California Institute for Research and Education; H. Lundbeck A/S; Alzheimer’s Research UK; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alzheimer's Drug Discovery Foundation; AbbVie; Massachusetts Institute of Technology; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; GE Healthcare; James S. McDonnell Foundation; Foundation for the National Institutes of Health; Meso Scale Diagnostics","keywords":"Segmentation; Diffusion MRI; Brainstem; Neuroanatomy; Brain atlas; Probabilistic logic; Neuroimaging; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0005157607,0.0002094994,0.0003258153,0.0004546366,0.0006770234,0.00009110036,0.0002916136,0.00007901841,0.00002608387],"category_scores_gemma":[0.02587342,0.0002335015,0.00009040258,0.0009119749,0.0003178625,0.0002104199,0.0002688755,0.0001617883,0.00006907144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001328157,"about_ca_system_score_gemma":0.00006966073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001883666,"about_ca_topic_score_gemma":0.00002535864,"domain_scores_codex":[0.9978706,0.0002934426,0.0004288103,0.0006427369,0.0003756983,0.0003886699],"domain_scores_gemma":[0.9860272,0.01331742,0.00009788905,0.0003218719,0.0001514197,0.00008418009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004843722,0.00008050672,0.001067909,0.0001902938,0.00002099747,0.00001102099,0.001674526,0.0001783002,0.8538337,0.06674429,0.07599537,0.0001982566],"study_design_scores_gemma":[0.004476638,0.0006909699,0.3195034,0.002152437,0.0001032378,0.00005745512,0.01760447,0.01606507,0.4950025,0.03476555,0.1086743,0.0009040276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430237,0.00003694695,0.01146251,0.01886176,0.0008857462,0.0007958293,0.00003600298,0.001062911,0.02383456],"genre_scores_gemma":[0.9818702,0.000001109544,0.0006581342,0.01545756,0.00006721679,0.00006687455,0.000003602779,0.00002250265,0.001852762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3588312,"threshold_uncertainty_score":0.9823321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04065183813711171,"score_gpt":0.3212447193030867,"score_spread":0.280592881165975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}