{"id":"W4415077664","doi":"10.1093/jbmrpl/ziaf160","title":"Identification of novel collagen breakdown products by human osteoclasts in vitro and in vivo","year":2025,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Collagen: Extraction and Characterization","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Bone resorption; Peptide; Cathepsin; Osteoclast; Cathepsin K; In vivo; Matrix metalloproteinase; Proteases; Resorption","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002373595,0.0002318062,0.0001888851,0.0002730044,0.0001271111,0.0002974118,0.00007346246,0.0001368273,0.0008078449],"category_scores_gemma":[0.0002757688,0.0001203064,0.0001748797,0.0002052753,0.0001176517,0.00006884745,0.0001366327,0.0002184607,0.0002993417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009530062,"about_ca_system_score_gemma":0.0001536451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007431397,"about_ca_topic_score_gemma":0.0008080563,"domain_scores_codex":[0.9998407,0.00003099297,0.00001286435,0.00002487443,0.00005320687,0.00003731936],"domain_scores_gemma":[0.9998399,0.00003949639,0.00003366332,0.00001267019,0.00003707177,0.00003718667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558878,0.00002548756,0.005259886,0.00005284445,0.00001089054,0.0001687893,0.00004450729,0.00002709302,0.9916807,0.00001927064,0.00003665923,0.002318067],"study_design_scores_gemma":[0.0002330718,0.002095974,0.2238935,0.00004196195,0.0001328261,0.006285957,0.0003939556,0.001587145,0.7588074,0.00009699472,0.006408045,0.00002310469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949532,0.003076117,0.00112702,0.00002634011,0.00001122201,0.000026772,0.0003376029,0.000008527047,0.0004331977],"genre_scores_gemma":[0.9941763,0.001410623,0.002178083,0.0000401006,0.00001499418,0.00003948854,0.001211972,0.000006021274,0.0009223938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008078449,"threshold_uncertainty_score":0.002702534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009741933603322388,"score_gpt":0.2631720740179211,"score_spread":0.2534301404145988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}