{"id":"W4415077881","doi":"10.1002/alz.70765","title":"Body mass index and blood volume influence plasma biomarkers and positron emission tomography classification in preclinical Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; IXICO; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; H. Lundbeck A/S; Servier; Fundación Tatiana Pérez de Guzmán el Bueno; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Eisai; Generalitat de Catalunya; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; BrightFocus Foundation; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Positron emission tomography; Blood volume; Body mass index; Plasma volume; Positron; Amyloid (mycology); Positron emission; Blood plasma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001119973,0.0003390856,0.0003051859,0.0006557595,0.0001810687,0.0006158914,0.0002495228,0.0003380315,0.001019842],"category_scores_gemma":[0.004428317,0.0001404282,0.0003942675,0.0007287383,0.0002125683,0.0002999424,0.0002838511,0.0002809214,0.0002316741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774941,"about_ca_system_score_gemma":0.0001529456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002472707,"about_ca_topic_score_gemma":0.002179418,"domain_scores_codex":[0.9994088,0.0002579256,0.00005608516,0.0001377969,0.0001004513,0.00003893771],"domain_scores_gemma":[0.9974179,0.001147522,0.0007799211,0.0002405759,0.0002595319,0.0001545747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000512964,0.00002256056,0.9934366,0.00001330407,0.0001799771,0.00003364647,0.00003746418,0.0001636569,0.0009898966,0.00003329646,0.00009228715,0.004484331],"study_design_scores_gemma":[0.000002912803,0.00007141201,0.9986156,0.000004562636,0.00004797568,0.00009199571,0.00001790053,0.0007267729,0.0002179156,0.00007538987,0.0001249447,0.000002632339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972304,0.0009222805,0.0007312271,0.00005210182,0.00001264805,0.000007156847,0.0003961394,0.00001444598,0.0006337753],"genre_scores_gemma":[0.9992704,0.00007847806,0.0002932123,0.00001597925,0.00001039856,0.000005660695,0.0001949263,0.000004560467,0.0001264252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472707,"threshold_uncertainty_score":0.005923033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972036357602217,"score_gpt":0.3234196636416876,"score_spread":0.3036993000656654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}