{"id":"W4415079377","doi":"10.1021/acssynbio.5c00395","title":"Thermally Controlled State Switches for Engineered Macrophages","year":2025,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Molecular Communication and Nanonetworks","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Natural Sciences and Engineering Research Council of Canada; Beckman Institute, California Institute of Technology; Howard Hughes Medical Institute; California Institute of Technology; Sontag Foundation; Paul and Daisy Soros Fellowships for New Americans; National Institutes of Health; Human Frontier Science Program; National Science Foundation","keywords":"Immune system; Secretion; Immunotherapy; Gene expression; Cell culture; Macrophage; Cytokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644009,0.0001205489,0.0002555732,0.00007291936,0.00004283825,0.00001238341,0.0002384312,0.0001106341,0.0000292845],"category_scores_gemma":[0.00006839331,0.0001021621,0.00007784488,0.00008483184,0.00004277992,0.000011551,0.00003487824,0.00009502551,0.00001358632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001574804,"about_ca_system_score_gemma":0.00001498796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002762794,"about_ca_topic_score_gemma":0.000005332446,"domain_scores_codex":[0.9994069,0.00004369049,0.0002044498,0.0001147708,0.00002058593,0.000209547],"domain_scores_gemma":[0.9992732,0.0003063174,0.00002185431,0.0003397273,0.00003337188,0.00002548216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003536196,0.0000775224,0.0001421013,0.000136385,0.0009628205,0.000002191691,0.0002298083,0.01255956,0.7818245,0.02990107,0.003137975,0.1706725],"study_design_scores_gemma":[0.01629487,0.0002708041,0.0009957351,0.0001939267,0.0003164276,0.00001398894,0.00009423884,0.293411,0.3179632,0.02693154,0.3423037,0.001210553],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1985757,0.02150514,0.7538055,0.002200309,0.001292068,0.001681151,0.00004956352,0.0008418548,0.02004875],"genre_scores_gemma":[0.9968599,0.000506366,0.001523328,0.0002082934,0.00001670901,0.0001922981,0.00001598613,0.00001803701,0.000659087],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7982842,"threshold_uncertainty_score":0.416605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007268076728737716,"score_gpt":0.2325056403614284,"score_spread":0.2252375636326907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}