{"id":"W4415087165","doi":"10.1016/j.mcpro.2025.101091","title":"Interaction Proteomics of Polycystins 1 and 2 Reveal a Novel Role for the BLOC-1/BORC Lysosomal Positioning Complex","year":2025,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Toronto Metropolitan University","keywords":"Endoplasmic reticulum; Cilium; Autosomal dominant polycystic kidney disease; PKD1; Polycystic kidney disease; Mutant; Biogenesis; Biotinylation; Proteomics; Organelle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798411,0.0002111022,0.0002025299,0.00006196136,0.0001950808,0.00005011235,0.0002325084,0.0001272649,0.000003602375],"category_scores_gemma":[0.0001422583,0.0001902008,0.0001648538,0.0001091954,0.0001475271,0.000004964025,0.0001802524,0.0001054645,6.850142e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001963858,"about_ca_system_score_gemma":0.0001638687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005340747,"about_ca_topic_score_gemma":0.000005527366,"domain_scores_codex":[0.9988708,0.00005220357,0.0003231715,0.0003831935,0.0001177909,0.0002528681],"domain_scores_gemma":[0.9991832,0.00002364633,0.0001625424,0.0004006845,0.0001523828,0.00007750591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000323301,0.0001019354,0.0003338557,0.00009651144,0.0001558023,0.000001202904,0.00003696154,0.0002802912,0.9977806,0.0003772999,0.0001435127,0.0003686783],"study_design_scores_gemma":[0.0010856,0.0001951676,0.001130966,0.00005535518,0.0001615796,0.00001496071,0.0001695679,0.003822162,0.9903165,0.0003898967,0.002470367,0.0001879078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7269524,0.00093179,0.2700151,0.0003728009,0.00007778144,0.001300986,0.00008740572,0.00001021391,0.0002515242],"genre_scores_gemma":[0.9676997,0.00003004504,0.03105949,0.0003680195,0.00007251644,0.0002700307,0.000222614,0.00003056923,0.0002470288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2407472,"threshold_uncertainty_score":0.7756162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00841646836665194,"score_gpt":0.243890234363948,"score_spread":0.2354737659972961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}