{"id":"W4415092713","doi":"10.1016/j.joca.2025.10.003","title":"Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts","year":2025,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Eurostars; DePuy Mitek; National Institutes of Health; Novartis Farmacéutica; Innovative Medicines Initiative; Celgene; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Stryker; Arthritis Society; Boehringer Ingelheim España; Eli Lilly and Company; Dutch Arthritis Society; European Federation of Pharmaceutical Industries and Associations; European Regional Development Fund; Merck KGaA; European Commission; Sanofi; Gedeon Richter; GlaxoSmithKline; CSL Behring; UCB US; AstraZeneca; Bristol-Myers Squibb; Sun Pharma; Novartis Pharmaceuticals Corporation; Pfizer; Universitair Medisch Centrum Utrecht; ZonMw; Arthritis Foundation; Amgen; Foundation for the National Institutes of Health","keywords":"Cartilage; Cartilage damage; Osteoarthritis; Knee cartilage; Articular cartilage damage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00164097,0.0002660217,0.0005841678,0.001118016,0.0002372986,0.0005783146,0.0004638437,0.0005205172,0.001161357],"category_scores_gemma":[0.002619212,0.0002148371,0.000879807,0.0007062121,0.0003912322,0.0006803575,0.0005727761,0.0003271736,0.00028499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706676,"about_ca_system_score_gemma":0.0001301823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430713,"about_ca_topic_score_gemma":0.002365286,"domain_scores_codex":[0.9991295,0.0001578579,0.000142961,0.0002609933,0.0001822656,0.0001265762],"domain_scores_gemma":[0.9967801,0.000316895,0.002143548,0.00027754,0.0002191391,0.0002628608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004509997,0.00001398419,0.997781,0.00001999371,0.0001161172,0.00003807149,0.00006701908,0.00001695002,0.0002866524,0.00000815804,0.00003575271,0.001165266],"study_design_scores_gemma":[0.000008289187,0.0001111945,0.9993518,0.000006551573,0.00003891177,0.0002090302,0.0001073021,0.00002565395,0.00004968141,0.00001013723,0.00007812183,0.00000332226],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988741,0.0004960863,0.00007843093,0.00001349684,0.000003204151,0.000006033162,0.0003261059,0.000001898654,0.0002005872],"genre_scores_gemma":[0.9990885,0.00008540083,0.00004420774,0.00001379817,0.000007406104,0.000007169403,0.000679835,0.000002013413,0.00007166195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00164097,"threshold_uncertainty_score":0.008678436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514095332213483,"score_gpt":0.2739962312266914,"score_spread":0.2488552779045566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}