{"id":"W4415101708","doi":"10.1016/j.jtha.2025.09.012","title":"Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis","year":2025,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Blood properties and coagulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Alnylam Pharmaceuticals; U.S. Department of Defense; Versiti Blood Research Institute Foundation","keywords":"Fibrinogen; Thrombosis; Nanoparticle; Hemostasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009791184,0.0005973972,0.0003078886,0.0003917937,0.0004021466,0.0005475043,0.0004612553,0.0009785743,0.002303133],"category_scores_gemma":[0.0005482733,0.0003024911,0.0006055918,0.0001678384,0.0006902283,0.0003793994,0.000146938,0.0009504569,0.0005950122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006583369,"about_ca_system_score_gemma":0.0008522284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002066699,"about_ca_topic_score_gemma":0.002675009,"domain_scores_codex":[0.9996127,0.00007292296,0.00002340483,0.000110617,0.00009380411,0.00008655629],"domain_scores_gemma":[0.9994129,0.0001170408,0.000176605,0.00007255539,0.0001152333,0.0001057085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004715437,0.002102487,0.0006633282,0.0001041452,0.0000539803,0.0001455115,0.00008646378,0.0004141461,0.9843721,0.000203648,0.0006009766,0.006537805],"study_design_scores_gemma":[0.000709424,0.08845919,0.003193669,0.00002454037,0.0002387713,0.0004575766,0.0001383414,0.00254954,0.8980726,0.0001692911,0.005951657,0.00003534305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852017,0.0007222659,0.01014677,0.0003581842,0.0001910316,0.0005733456,0.0006822606,0.0002074068,0.001917002],"genre_scores_gemma":[0.9796574,0.0009444408,0.008891123,0.0003758437,0.00006038331,0.0004681356,0.001334387,0.00008640927,0.008181956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002303133,"threshold_uncertainty_score":0.007704735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1620517820788219,"score_gpt":0.3807345129949797,"score_spread":0.2186827309161578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}