{"id":"W4415101989","doi":"10.3390/biology14101402","title":"Unraveling Melasma: From Epidermal Pigmentation to Microenvironmental Dysregulation","year":2025,"lang":"en","type":"review","venue":"Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Melasma; Melanosome; Pathogenesis; Hyperpigmentation; Subclinical infection; Melanin; Melanocyte; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001241901,0.0003111044,0.0005640797,0.0001186809,0.00007502881,0.00001779534,0.0002079334,0.0004902824,0.0001083518],"category_scores_gemma":[0.00005503817,0.0002925449,0.0002093625,0.00009341982,0.00003910754,0.000002453462,0.0001713246,0.0000949792,0.000132784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007816366,"about_ca_system_score_gemma":0.00009198091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003728492,"about_ca_topic_score_gemma":0.00001579244,"domain_scores_codex":[0.9983259,0.0002635823,0.000478788,0.0006338769,0.00006467685,0.0002332171],"domain_scores_gemma":[0.9993349,0.00005744079,0.0002014345,0.0003192953,0.00001664998,0.00007027081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004033028,0.00004674446,0.0001050831,0.0006951562,0.0002433423,0.00000230533,0.00002916437,0.000009449514,0.03353691,0.000112537,0.003422037,0.9617569],"study_design_scores_gemma":[0.000268405,0.0001265052,0.0001009253,0.0006711014,0.0002472387,0.000006854547,0.00001958422,0.000003628079,0.004191786,0.00004965072,0.99399,0.0003243327],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002719473,0.9887788,0.00606073,0.00003689767,0.0008826011,0.0007557086,0.0003544558,0.0000149198,0.0003963934],"genre_scores_gemma":[0.0006748449,0.9780727,0.002405566,0.0002536249,0.0005840118,0.000146939,0.01704213,0.00003035908,0.0007898051],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905679,"threshold_uncertainty_score":0.9999527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223657655876444,"score_gpt":0.3424047785498394,"score_spread":0.320168201991075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}