{"id":"W4415101989","doi":"10.3390/biology14101402","title":"Unraveling Melasma: From Epidermal Pigmentation to Microenvironmental Dysregulation","year":2025,"lang":"en","type":"review","venue":"Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Melasma; Melanosome; Pathogenesis; Hyperpigmentation; Subclinical infection; Melanin; Melanocyte; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765912,0.0006388559,0.0009575835,0.0009883775,0.0002926027,0.001531968,0.0006187278,0.0009990637,0.001955935],"category_scores_gemma":[0.0003802634,0.0001817627,0.0004157693,0.0007107523,0.000713796,0.00187819,0.0007639701,0.00213788,0.0006204708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006200133,"about_ca_system_score_gemma":0.001017547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009436453,"about_ca_topic_score_gemma":0.001181403,"domain_scores_codex":[0.9998313,0.00003921374,0.00002250031,0.00003653951,0.00004295269,0.00002748254],"domain_scores_gemma":[0.9998208,0.00005784244,0.00002928409,0.000005963153,0.00005706495,0.00002906421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002634557,0.0001036478,0.00131526,0.0288384,0.0001972711,0.00271104,0.0008078418,0.0007374473,0.0336939,0.02168038,0.04873481,0.8609166],"study_design_scores_gemma":[0.00001551587,0.0002369906,0.002621652,0.003551424,0.0001517958,0.006264629,0.0005559811,0.0003785246,0.002903028,0.008575334,0.9747079,0.00003722158],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009085063,0.9954449,0.0004752906,0.001426567,0.000570685,0.000005606315,0.00002106881,0.0000177395,0.001129716],"genre_scores_gemma":[0.006069418,0.9901754,0.000471035,0.001086362,0.001042671,0.000008437069,0.00004477777,0.000005618157,0.001096251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001955935,"threshold_uncertainty_score":0.006543219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223657655876444,"score_gpt":0.3424047785498394,"score_spread":0.320168201991075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}