{"id":"W4415105706","doi":"10.1021/acs.oprd.5c00271","title":"A Second-Generation Route to the Cereblon Fragment of ARV-471, Vepdegestrant","year":2025,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alphora Research (Canada)","funders":"","keywords":"Linker; Cereblon; Moiety; Fragment (logic); Reductive amination; Chimera (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387303,0.0003387341,0.0002426163,0.0002412914,0.0001221675,0.0002504818,0.0002860544,0.000327411,0.002954232],"category_scores_gemma":[0.0001212446,0.0001007547,0.0002519702,0.000148617,0.0001739237,0.0003336189,0.0002232432,0.0008084745,0.001060918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379918,"about_ca_system_score_gemma":0.0003383058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006596231,"about_ca_topic_score_gemma":0.0006621495,"domain_scores_codex":[0.999926,0.000008253873,0.000003561557,0.00001900364,0.00001850153,0.00002474261],"domain_scores_gemma":[0.9999675,0.000004392737,0.000009806818,0.000003855653,0.000005070533,0.000009419889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009830962,0.0001921968,0.0003368611,0.000803966,0.00006833977,0.002127491,0.0001614384,0.001084204,0.8879532,0.008417259,0.007010221,0.0908617],"study_design_scores_gemma":[0.0002378449,0.002118755,0.0009096095,0.00004669804,0.00005987753,0.006536915,0.00004737877,0.0008466389,0.8551457,0.0008441939,0.1331695,0.00003689324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6698598,0.1101516,0.1143812,0.003002913,0.001181702,0.0008415415,0.004496556,0.001272974,0.09481166],"genre_scores_gemma":[0.9442966,0.021282,0.01470757,0.0004829118,0.00006671511,0.0001388251,0.001128628,0.00008249569,0.01781414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002954232,"threshold_uncertainty_score":0.009882927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552102592395164,"score_gpt":0.3335557254423925,"score_spread":0.3080346995184409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}