{"id":"W4415105706","doi":"10.1021/acs.oprd.5c00271","title":"A Second-Generation Route to the Cereblon Fragment of ARV-471, Vepdegestrant","year":2025,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alphora Research (Canada)","funders":"","keywords":"Linker; Cereblon; Moiety; Fragment (logic); Reductive amination; Chimera (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008781145,0.0001212696,0.0001138179,0.0001263795,0.0002292487,0.00004699696,0.0004177678,0.00009231296,0.0001753542],"category_scores_gemma":[0.0002451146,0.00009102699,0.00002855129,0.0005035008,0.00005395519,0.00000642558,0.0002299748,0.0001606163,0.00004812931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000880903,"about_ca_system_score_gemma":0.001113082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005943015,"about_ca_topic_score_gemma":0.0002503228,"domain_scores_codex":[0.9984835,0.0001024621,0.0003054722,0.0003510429,0.0004498707,0.00030762],"domain_scores_gemma":[0.9991503,0.00001225942,0.00004876713,0.0003335421,0.0003729128,0.00008217368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004632693,0.00008816247,0.0003658124,0.00008186131,0.00005691553,6.802429e-7,0.0004592256,0.00001376575,0.9716304,0.0002205915,0.01499775,0.01203853],"study_design_scores_gemma":[0.0002138936,0.00008203857,0.002079764,0.00004277491,0.00000244677,0.00000128701,0.0001284809,0.0000121222,0.841832,0.00004948898,0.1554684,0.00008727824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893768,0.0005794053,0.003142852,0.002951539,0.0001577225,0.0007947505,0.00000868159,0.00001209157,0.002976131],"genre_scores_gemma":[0.9927241,0.00009781215,0.000635855,0.0003450744,0.00009605265,0.000203029,0.0000820596,0.00001301759,0.005802983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1404707,"threshold_uncertainty_score":0.3711973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552102592395164,"score_gpt":0.3335557254423925,"score_spread":0.3080346995184409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}