{"id":"W4415106482","doi":"10.26508/lsa.202403020","title":"Mitochondrial dysfunction alters early endosome trafficking via microtubule reorganization","year":2025,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Endocytic cycle; Mitochondrion; Endosome; Microtubule; Bioenergetics; Centrosome; Cellular compartment; Reactive oxygen species; Cell physiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314157,0.000142613,0.0001235413,0.00009196217,0.000369317,0.00008238624,0.0003578968,0.0001282906,0.00005655003],"category_scores_gemma":[0.000473602,0.0001463164,0.00005472912,0.0007327048,0.0002994337,0.00002581225,0.0000882302,0.0001256145,0.00007658337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003307003,"about_ca_system_score_gemma":0.0002781153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001402714,"about_ca_topic_score_gemma":0.00001718257,"domain_scores_codex":[0.9985638,0.00006621193,0.0002315739,0.0006221721,0.0001881507,0.000328151],"domain_scores_gemma":[0.9992328,0.00001432681,0.00008878905,0.000383632,0.000169461,0.0001109395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009005638,0.00002427658,0.001663552,0.000007418588,0.000008313556,0.000001032306,0.00006002991,0.0001957695,0.9931137,0.0003584979,0.003314327,0.001163036],"study_design_scores_gemma":[0.001096327,0.0002672438,0.005944248,0.00003535124,0.0000198453,0.00001310836,0.00007311477,0.0003801856,0.9198484,0.0001755128,0.07184043,0.000306171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8230109,0.00037245,0.1642206,0.0009257282,0.007977808,0.0004364169,0.000006361827,0.00007071062,0.002979042],"genre_scores_gemma":[0.9870521,0.0001016194,0.004139019,0.002525377,0.0008859297,0.00003035925,0.00003250866,0.00001606411,0.00521704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1640412,"threshold_uncertainty_score":0.5966611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00795044584759202,"score_gpt":0.2440369678817773,"score_spread":0.2360865220341853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}