{"id":"W4415112786","doi":"10.1093/jalm/jfaf149","title":"Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease","year":2025,"lang":"en","type":"article","venue":"The Journal of Applied Laboratory Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AbbVie Canada; Crohn's and Colitis UK; MSD K.K.; Guts UK; Merck Sharp and Dohme; Royal Devon and Exeter NHS Foundation Trust","keywords":"Adalimumab; Infliximab; Antibody; Drug; Crohn's disease; Disease; Inflammatory bowel disease; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001828241,0.0003298082,0.0006253931,0.000256296,0.0001405591,0.0000287299,0.0003614686,0.0001021457,0.000005850902],"category_scores_gemma":[0.0006602003,0.0001846984,0.00005456351,0.0005181647,0.0003567642,0.00002906929,0.0001209748,0.0003542996,8.26648e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914236,"about_ca_system_score_gemma":0.0009083328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001976467,"about_ca_topic_score_gemma":0.0003409252,"domain_scores_codex":[0.9974477,0.000650425,0.0008446762,0.0003176905,0.0003925316,0.0003469377],"domain_scores_gemma":[0.9980162,0.0003899568,0.0006014463,0.0005092637,0.0002242672,0.0002588879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5773162,0.0008917385,0.3361965,0.0001795749,0.0002375258,0.001226523,0.001229855,0.002782791,0.0790868,0.00003217315,0.0004644596,0.0003558584],"study_design_scores_gemma":[0.0111593,0.0005445658,0.9750814,0.0006268666,0.0001659235,0.000002182195,0.001498274,0.00001940952,0.01030282,0.00001784458,0.0003557176,0.0002256628],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978886,0.00007147241,0.00004796892,0.00103525,0.0001008701,0.0007451035,0.0000793632,0.000009717405,0.00002164728],"genre_scores_gemma":[0.9987487,0.00009683233,0.00008747819,0.0008856276,0.0001005721,0.00001657849,0.000007814961,0.00002772055,0.00002866866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.638885,"threshold_uncertainty_score":0.7531783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772256390750881,"score_gpt":0.3164519016977023,"score_spread":0.2887293377901935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}