{"id":"W4415112786","doi":"10.1093/jalm/jfaf149","title":"Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease","year":2025,"lang":"en","type":"article","venue":"The Journal of Applied Laboratory Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AbbVie Canada; Crohn's and Colitis UK; MSD K.K.; Guts UK; Merck Sharp and Dohme; Royal Devon and Exeter NHS Foundation Trust","keywords":"Adalimumab; Infliximab; Antibody; Drug; Crohn's disease; Disease; Inflammatory bowel disease; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001954762,0.0003138644,0.0005314466,0.001040102,0.0002533145,0.0007881105,0.0004514738,0.0007771575,0.001220701],"category_scores_gemma":[0.005574927,0.0001827903,0.0002649998,0.0005169149,0.000575047,0.001646353,0.000495887,0.0007458304,0.0002614888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003481881,"about_ca_system_score_gemma":0.0002895581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203281,"about_ca_topic_score_gemma":0.001533673,"domain_scores_codex":[0.9986846,0.0005151714,0.0001938855,0.0001732709,0.0002651966,0.000167836],"domain_scores_gemma":[0.9961267,0.001724017,0.001486052,0.000122148,0.0003055158,0.0002355513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001416027,0.00004552408,0.9870448,0.0000741041,0.00003211314,0.0001441188,0.0001556069,0.00005847304,0.0003056808,0.00003439004,0.0001652605,0.01179836],"study_design_scores_gemma":[0.000008662643,0.0002649724,0.9957146,0.0000821475,0.00004089874,0.001915525,0.0005258528,0.0005153164,0.0002041722,0.0001134336,0.0006083845,0.000006036051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900796,0.007382619,0.0004601284,0.0007760517,0.00002763668,0.000008506176,0.00007143745,0.000006165229,0.001187849],"genre_scores_gemma":[0.9988397,0.0007583253,0.0001075107,0.0001387825,0.00005769571,0.000002576008,0.0000373834,0.000001006445,0.00005709095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954762,"threshold_uncertainty_score":0.01033789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772256390750881,"score_gpt":0.3164519016977023,"score_spread":0.2887293377901935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}