{"id":"W4415116673","doi":"10.3390/biom15101441","title":"Platelet Polyphosphate Signals Through NFκB to Induce Myofibroblast Differentiation","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; National Institutes of Health","keywords":"Myofibroblast; Wound healing; Intracellular; Signal transduction; Platelet; Fibroblast; Receptor; Inflammation; Platelet factor 4","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000961464,0.0002672756,0.0003695462,0.0002154975,0.0001526427,0.00007423303,0.0001445649,0.0001586257,0.0001903449],"category_scores_gemma":[0.0001002258,0.0002430685,0.0001598912,0.000667082,0.00008270122,0.0001305973,0.00009358691,0.00009548164,0.0001804529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007636818,"about_ca_system_score_gemma":0.0001266346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004517194,"about_ca_topic_score_gemma":0.00005799677,"domain_scores_codex":[0.9984199,0.00004034505,0.0004126946,0.0004458025,0.0002911424,0.0003901306],"domain_scores_gemma":[0.9991811,0.00007170769,0.00009708675,0.0003698051,0.0001249159,0.0001554183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001523,0.0007950419,0.02864761,0.0004238693,0.000690277,0.000109481,0.002219538,0.0000539902,0.7893704,0.04034769,0.03941652,0.09692409],"study_design_scores_gemma":[0.001901709,0.0002955127,0.1422775,0.000593569,0.0001450729,0.00001835673,0.0002521627,0.0002453074,0.8255941,0.002308619,0.02598185,0.0003862537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682584,0.002674787,0.01682355,0.006343205,0.0005186388,0.0007050426,0.00003227072,0.0002543293,0.004389768],"genre_scores_gemma":[0.9914436,0.00007064492,0.00162068,0.003064266,0.0001593163,0.00003669342,0.0001148095,0.00003254589,0.00345748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1136299,"threshold_uncertainty_score":0.9912044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576712105874905,"score_gpt":0.2948498741977243,"score_spread":0.2790827531389752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}