{"id":"W4415127040","doi":"10.1021/acs.est.4c13900","title":"Disinfection Byproducts Confirmed over 50 Years: Systematic Curation, Modes of Toxic Action, and Toxicogenomics","year":2025,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Toxicogenomics; Identification (biology); Metabolome; Transcriptome; Human health; Risk assessment; Human proteome project; Genomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006771467,0.0009852279,0.001525029,0.008155677,0.001028482,0.002544833,0.000896132,0.000772663,0.001314822],"category_scores_gemma":[0.007885178,0.0003883359,0.001664682,0.007122119,0.001067402,0.001957843,0.001904231,0.001486673,0.0005967746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002139458,"about_ca_system_score_gemma":0.008623828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009360298,"about_ca_topic_score_gemma":0.02186578,"domain_scores_codex":[0.9961475,0.0006260364,0.0005730426,0.000778911,0.001694062,0.0001803995],"domain_scores_gemma":[0.9891003,0.002278654,0.002147373,0.0009152842,0.00531099,0.0002474075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000397801,0.0001196114,0.05636857,0.05614379,0.002146609,0.001874083,0.001906533,0.002244124,0.1039571,0.007740253,0.01831341,0.7487881],"study_design_scores_gemma":[0.00002933024,0.0004829708,0.06777983,0.01224917,0.003775585,0.002479892,0.001955087,0.0008394916,0.1059833,0.005757242,0.7984809,0.0001871464],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07429056,0.8643939,0.03172216,0.002924673,0.001440777,0.0003771094,0.01261492,0.0003860935,0.01184975],"genre_scores_gemma":[0.1730948,0.7607951,0.03869582,0.003319046,0.0005178658,0.000254886,0.01844,0.0002510799,0.004631446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009360298,"threshold_uncertainty_score":0.03581131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005550098647171366,"score_gpt":0.2244876767482512,"score_spread":0.2189375781010799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}