{"id":"W4415127488","doi":"10.1021/acs.molpharmaceut.5c01339","title":"Supramolecular Chemistry Enables Radiolabeling of Proteins under Mild Conditions","year":2025,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Submarine Engineering (Canada)","funders":"Conseil régional de Bourgogne-Franche-Comté; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; European Commission","keywords":"Supramolecular chemistry; In vivo; Conjugated system; In vitro; Monoclonal antibody; Covalent bond; Supramolecular assembly","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335492,0.0003893367,0.0002497589,0.0001660426,0.0001467713,0.000291559,0.000215957,0.0003653362,0.001520497],"category_scores_gemma":[0.0002006482,0.0001686076,0.0002231822,0.0001440026,0.0002831781,0.0003666238,0.0003954924,0.0005796691,0.0006723388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593664,"about_ca_system_score_gemma":0.0002203398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319646,"about_ca_topic_score_gemma":0.0002319275,"domain_scores_codex":[0.9998215,0.00002820341,0.00001395858,0.00005003139,0.00004766327,0.00003868545],"domain_scores_gemma":[0.9999027,0.00002260132,0.00003593053,0.00001516456,0.000009955166,0.00001365792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001906718,0.00001185388,0.00003537175,0.00007401651,0.000004291473,0.0000309832,0.0000150239,0.0001519105,0.9957827,0.0007473869,0.00007172353,0.003055549],"study_design_scores_gemma":[0.000009086647,0.0001343651,0.0002456114,0.000004764952,0.000006420903,0.0001034294,0.000008264235,0.001060668,0.9918017,0.0002742183,0.006344588,0.000007004087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8901513,0.006652209,0.08692344,0.0004895776,0.0001945228,0.0001817149,0.0005328006,0.001180927,0.0136935],"genre_scores_gemma":[0.9829899,0.001462283,0.01233169,0.0001472925,0.00004928628,0.000139959,0.0001898235,0.00004572224,0.002643928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520497,"threshold_uncertainty_score":0.005086541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525978527736274,"score_gpt":0.3688115908537965,"score_spread":0.3435518055764338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}