{"id":"W4415130055","doi":"10.1128/jvi.01034-25","title":"Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; Université de Montréal","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Viral replication; Neutralization; Viral entry; Potency; Transgene; Glycoprotein; Coronavirus; Mutation; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184759,0.0004748989,0.000432077,0.0002972596,0.0001287891,0.000352402,0.0003654391,0.0003121994,0.001778784],"category_scores_gemma":[0.0001950607,0.0001478029,0.0002846669,0.0002637533,0.0001326285,0.0002708479,0.00023066,0.0005017792,0.0004803217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580005,"about_ca_system_score_gemma":0.0001700168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005275312,"about_ca_topic_score_gemma":0.0007222387,"domain_scores_codex":[0.9998864,0.00001914591,0.00001258565,0.000020184,0.00002706151,0.00003459088],"domain_scores_gemma":[0.9999353,0.00001090066,0.00001367455,0.000004309562,0.00001409117,0.0000217517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000791796,0.0008599623,0.0004186126,0.0001961303,0.00005141084,0.0002565417,0.00004070386,0.003863868,0.9756494,0.0006727781,0.0004381414,0.01676065],"study_design_scores_gemma":[0.0006245626,0.009069377,0.002092362,0.0000457825,0.00009772775,0.0005765198,0.00006011572,0.007711771,0.966327,0.0001916106,0.01315994,0.00004323272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989132,0.002470748,0.003557036,0.00009422946,0.00006222126,0.0001804267,0.0005128197,0.00008775816,0.003902731],"genre_scores_gemma":[0.9928514,0.001283994,0.00327247,0.00009191142,0.000009025382,0.00006971013,0.0006886976,0.00002392249,0.001709005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778784,"threshold_uncertainty_score":0.00595063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02599572936948657,"score_gpt":0.3382959059100039,"score_spread":0.3123001765405173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}