{"id":"W4415133357","doi":"10.1007/s13555-025-01543-7","title":"Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Clinical trial; Alopecia areata; Phase (matter); Phases of clinical research; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02857555,0.00399877,0.003262646,0.001051884,0.001889164,0.002047148,0.002676588,0.004126011,0.01494157],"category_scores_gemma":[0.01261307,0.002043362,0.001890855,0.00088367,0.004205212,0.00215291,0.001146496,0.004825772,0.004550713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001419483,"about_ca_system_score_gemma":0.007971812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360147,"about_ca_topic_score_gemma":0.001011226,"domain_scores_codex":[0.9847136,0.009139302,0.0007926291,0.00246832,0.001794573,0.001091587],"domain_scores_gemma":[0.9931989,0.001760373,0.001565505,0.0008215423,0.0009109295,0.00174271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8586702,0.03437505,0.006845575,0.007184077,0.001590532,0.0004951416,0.000536492,0.003027606,0.01597372,0.009581666,0.00993436,0.05178567],"study_design_scores_gemma":[0.7450728,0.1835772,0.007586837,0.0009583675,0.001421301,0.0003150231,0.000131797,0.003098609,0.003694676,0.006881186,0.04709628,0.0001658282],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.06448939,0.003032757,0.0135559,0.002484473,0.002091853,0.9034536,0.003117515,0.0002740159,0.007500557],"genre_scores_gemma":[0.1137602,0.0009020317,0.01833137,0.003744252,0.0007383282,0.8592858,0.0008664426,0.00002348706,0.002348104],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02857555,"threshold_uncertainty_score":0.1511237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657944768740517,"score_gpt":0.3830563487242735,"score_spread":0.3172618718502218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}