{"id":"W4415147243","doi":"10.1016/j.ebiom.2025.105964","title":"Using gene-environment interactions to explore pathways for colorectal cancer risk","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Memorial University of Newfoundland; Impact","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Junta de Castilla y León; Junta de Andalucía; Fonds de Recherche en Santé Respiratoire; Agència de Gestió d'Ajuts Universitaris i de Recerca; Nationales Centrum für Tumorerkrankungen Heidelberg; Region Skåne; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Deutsche Krebshilfe; Australian Institute of Health and Welfare, Australian Government; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Medizinische Universität Graz; Institut Gustave-Roussy; Compagnia di San Paolo; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Austrian Science Fund; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Conseil Régional des Pays de la Loire; Génome Québec; European Cooperation in Science and Technology; Generalitat de Catalunya; Imperial College London; Ligue Contre le Cancer; Federación Española de Enfermedades Raras; Food Standards Agency; Department of Pathology, Northwestern University; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Rollins School of Public Health; Maryland Department of Health; National Research Council; State of Maryland; Bundesministerium für Bildung und Forschung; Office of Infrastructure; Österreichische Forschungsförderungsgesellschaft; Swedish Cancer Foundation; Johns Hopkins University; Centre International de Recherche sur le Cancer; McGill University; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Division of Cancer Prevention, National Cancer Institute; Cancer Council Victoria; Kræftens Bekæmpelse; Victorian Cancer Agency; University of Pittsburgh; World Cancer Research Fund International; Association Anne de Bretagne Genetique; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; Baden-Württemberg Stiftung; Damon Runyon Cancer Research Foundation; Mutuelle Générale de l'Education Nationale; Ministerie van Volksgezondheid, Welzijn en Sport; U.S. Department of Health and Human Services; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research; Deutsche Forschungsgemeinschaft; Ministerstvo Zdravotnictví Ceské Republiky; VicHealth; American Cancer Society; Rajavithi Hospital","keywords":"Colorectal cancer; Cancer; MEDLINE; Grant funding","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002702515,0.001246123,0.0008384963,0.003655902,0.0007901313,0.001575171,0.0005791807,0.0004754231,0.005294017],"category_scores_gemma":[0.006964933,0.0003546104,0.003676355,0.003250611,0.000599535,0.0007622424,0.001809522,0.001279478,0.0006146966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006167385,"about_ca_system_score_gemma":0.001369663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004832624,"about_ca_topic_score_gemma":0.0068008,"domain_scores_codex":[0.9981807,0.0006400042,0.00008670615,0.0007303677,0.0001817178,0.0001804461],"domain_scores_gemma":[0.9933508,0.005130874,0.0007211478,0.0003536674,0.000188007,0.0002555035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00184231,0.0002356302,0.8405831,0.00220718,0.012395,0.001043915,0.0006718711,0.02662281,0.03933978,0.004228285,0.002587925,0.06824221],"study_design_scores_gemma":[0.0002070881,0.001069691,0.8589948,0.0003284633,0.007241291,0.001663874,0.0007132296,0.07062604,0.007692992,0.03632346,0.01491584,0.0002231863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8663995,0.008229102,0.09578846,0.001363956,0.000152135,0.0001837921,0.02258592,0.001688438,0.003608749],"genre_scores_gemma":[0.9558486,0.001232108,0.03464764,0.0002694119,0.00005332141,0.0002224535,0.006810972,0.0001847936,0.0007307859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005294017,"threshold_uncertainty_score":0.01771027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04662505445667427,"score_gpt":0.3425156309976649,"score_spread":0.2958905765409906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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