{"id":"W4415147298","doi":"10.1093/ibd/izaf212","title":"How Should an IBD Prevention Trial Be Designed?","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Genentech; Sun Pharma; Swedish Orphan Biovitrum; Otsuka Pharmaceutical; Allergan; Argenx; Celltrion; Teva Pharmaceutical Industries; Janssen Pharmaceuticals; Gilead Sciences; Sanofi; Astellas Pharma; Mylan; GlaxoSmithKline; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Clinical trial; Inflammatory bowel disease; MEDLINE; Inflammatory Bowel Diseases; Crohn's disease; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3204702,0.001730735,0.01037806,0.002209106,0.002521081,0.01317919,0.004518522,0.0216274,0.006512317],"category_scores_gemma":[0.5029378,0.001783249,0.006152304,0.002114118,0.00602984,0.01370543,0.003520728,0.01587301,0.004482906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005856964,"about_ca_system_score_gemma":0.03065746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928364,"about_ca_topic_score_gemma":0.002718723,"domain_scores_codex":[0.5683773,0.3746788,0.03119847,0.007237495,0.01622831,0.002279731],"domain_scores_gemma":[0.4640149,0.4485293,0.02825099,0.01754667,0.02958563,0.01207252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.02669699,0.001601544,0.009666414,0.1282604,0.009771637,0.0008238515,0.00257933,0.004895186,0.001472148,0.07836392,0.1543475,0.581521],"study_design_scores_gemma":[0.0561846,0.009585934,0.01073093,0.2567713,0.01218642,0.0009519461,0.002729881,0.006937701,0.002198955,0.2845821,0.3562923,0.0008478335],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.007658663,0.2553488,0.05149388,0.5603086,0.06488136,0.04752615,0.001840006,0.0007897114,0.01015294],"genre_scores_gemma":[0.07273304,0.08539148,0.2958425,0.4047847,0.02656702,0.109367,0.00154238,0.0004413314,0.003330639],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.3204702,"threshold_uncertainty_score":0.8379812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974047705845539,"score_gpt":0.2824635394698169,"score_spread":0.2627230624113615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}