{"id":"W4415151966","doi":"10.1186/s12943-025-02451-2","title":"Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"College of Family Physicians of Canada; University of Toronto","funders":"Siemens Healthineers; Christian Doppler Forschungsgesellschaft; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Universität Wien; Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; Hungarian Scientific Research Fund; Österreichische Forschungsförderungsgesellschaft; Magyar Tudományos Akadémia; Vienna Science and Technology Fund; Austrian Science Fund; National Research, Development and Innovation Office; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Medizinische Universität Wien; European Commission; Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung","keywords":"Prostate cancer; Androgen receptor; Carcinogenesis; Thyroid hormone receptor; Thyroid; Thyroid cancer; Cell growth; Context (archaeology); Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247155,0.0002188248,0.000431578,0.0001959673,0.00008405267,0.00002062375,0.0001374108,0.0001027205,0.0007627584],"category_scores_gemma":[0.00001745819,0.0001759225,0.0001725,0.0006687531,0.0001431591,0.0000876373,0.00008810027,0.000228121,0.00001536018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003612725,"about_ca_system_score_gemma":0.0008423001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00145213,"about_ca_topic_score_gemma":0.00001712649,"domain_scores_codex":[0.9983733,0.00004162614,0.0002873742,0.0004137628,0.0004289002,0.0004550022],"domain_scores_gemma":[0.9990337,0.0000189138,0.00009144112,0.0003016915,0.0004211707,0.0001330383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008678663,0.00014987,0.02938367,0.0004095867,0.0008494027,0.00006023758,0.0006634274,0.00004143924,0.9320078,0.000224427,0.03216079,0.003181414],"study_design_scores_gemma":[0.003357115,0.0002192698,0.003053954,0.0004458412,0.0002946712,0.000001035503,0.00007697688,0.00008292239,0.9719098,0.0002019626,0.02017854,0.0001778997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8730108,0.1116919,0.0002958298,0.009687327,0.0002440821,0.001144676,0.0002185173,0.0000579658,0.003648916],"genre_scores_gemma":[0.9660065,0.01241688,0.000700925,0.001679687,0.0000816973,0.0005353216,0.00005959596,0.00004754905,0.01847184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09927498,"threshold_uncertainty_score":0.8351669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132817604034568,"score_gpt":0.2959016593261907,"score_spread":0.284573483285845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}