{"id":"W4415151966","doi":"10.1186/s12943-025-02451-2","title":"Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"College of Family Physicians of Canada; University of Toronto","funders":"Siemens Healthineers; Christian Doppler Forschungsgesellschaft; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Universität Wien; Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; Hungarian Scientific Research Fund; Österreichische Forschungsförderungsgesellschaft; Magyar Tudományos Akadémia; Vienna Science and Technology Fund; Austrian Science Fund; National Research, Development and Innovation Office; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Medizinische Universität Wien; European Commission; Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung","keywords":"Prostate cancer; Androgen receptor; Carcinogenesis; Thyroid hormone receptor; Thyroid; Thyroid cancer; Cell growth; Context (archaeology); Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023247,0.0003156032,0.0002319879,0.0001999216,0.0001797217,0.0003142081,0.0001940938,0.0001593987,0.001760751],"category_scores_gemma":[0.00006367885,0.0001088539,0.0001783225,0.0002460967,0.0002058886,0.00008317617,0.0001762401,0.0006879994,0.0005475941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331915,"about_ca_system_score_gemma":0.0004397392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002201564,"about_ca_topic_score_gemma":0.003583071,"domain_scores_codex":[0.9998939,0.00001237096,0.000003579708,0.00002169635,0.00004278922,0.00002564464],"domain_scores_gemma":[0.9999613,0.000003408732,0.00001154754,0.000004616005,0.000007595468,0.00001157881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002566559,0.00007974241,0.002794644,0.0002599097,0.00003719822,0.0002972052,0.00003456505,0.0002993683,0.9576011,0.001293559,0.001736039,0.03530995],"study_design_scores_gemma":[0.0001030201,0.001265235,0.03952491,0.00005672278,0.0001902763,0.003674921,0.0001613044,0.002273801,0.7958008,0.0009777147,0.1559382,0.0000330779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8258326,0.1119735,0.01967296,0.002525369,0.0004289841,0.0001581265,0.003204374,0.001360134,0.03484392],"genre_scores_gemma":[0.9709352,0.01986354,0.001557044,0.0003222594,0.0000547804,0.0000461512,0.0009810183,0.00003648361,0.00620358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002201564,"threshold_uncertainty_score":0.00589031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132817604034568,"score_gpt":0.2959016593261907,"score_spread":0.284573483285845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}