{"id":"W4415156561","doi":"10.1186/s41181-025-00391-2","title":"Quantitative dual-isotope preclinical SPECT/CT imaging and biodistribution of the mercury-197m/g theranostic pair with [197m/gHg]HgCl2 and a [197m/gHg]Hg-tetrathiol complex as a platform for radiopharmaceutical development","year":2025,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; University of Toronto; TRIUMF","keywords":"Biodistribution; In vivo; Preclinical imaging; Molecular imaging; Medical imaging; Clinical imaging; Pet imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004423941,0.0003963941,0.0002539374,0.0002909687,0.0001188806,0.0002776058,0.0003351833,0.0005409832,0.001033187],"category_scores_gemma":[0.0001720184,0.0002238644,0.000154602,0.0002211809,0.000275396,0.0001687872,0.0002096267,0.0003316661,0.0002537508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281762,"about_ca_system_score_gemma":0.0003612555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115997,"about_ca_topic_score_gemma":0.001284265,"domain_scores_codex":[0.9998879,0.00002925019,0.000005738174,0.00002224847,0.00002931235,0.00002546063],"domain_scores_gemma":[0.999946,0.00001078553,0.00001469979,0.000005095788,0.00001203386,0.00001141305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299027,0.00001899642,0.000110842,0.00002188436,0.000004555391,0.00004804035,0.00001156284,0.0002168166,0.9982781,0.00006486026,0.00005878398,0.001035596],"study_design_scores_gemma":[0.00001912081,0.0003661736,0.0006704142,0.000003676304,0.00001940302,0.0001202238,0.0000123785,0.004596441,0.9931624,0.00002329308,0.0009987357,0.000007646891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721511,0.0008538647,0.02431683,0.0001313327,0.00002618576,0.0001302726,0.0002011293,0.0002457548,0.001943579],"genre_scores_gemma":[0.9627411,0.000471324,0.03259801,0.00008536199,0.000009180263,0.0001253579,0.0003476219,0.00006782707,0.003554113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115997,"threshold_uncertainty_score":0.003456354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04610131961789679,"score_gpt":0.3724856171040168,"score_spread":0.32638429748612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}