{"id":"W4415166000","doi":"10.1172/jci.insight.190227","title":"C1q limits cystoid edema by maintaining basal β-catenin–dependent signaling and blood-retina barrier function","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Eye Institute; National Institute on Drug Abuse","keywords":"Macular edema; Retinal; Context (archaeology); Edema; Complement system; Phenotype; Macular degeneration; Blood–retinal barrier","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096957,0.0002272813,0.0002996845,0.0001273439,0.000196271,0.00005800431,0.00005382393,0.0001217943,0.0002326043],"category_scores_gemma":[0.00008303447,0.0001840311,0.0001031668,0.0001733545,0.00005501767,0.00009660258,0.00005293565,0.0001703122,0.00003763249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006617818,"about_ca_system_score_gemma":0.00008985875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005342835,"about_ca_topic_score_gemma":0.000004164498,"domain_scores_codex":[0.9986884,0.00005361477,0.000278593,0.0004152848,0.0002693996,0.0002946881],"domain_scores_gemma":[0.9993185,0.00007868734,0.00007715797,0.0002044512,0.00008789883,0.0002332642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006290783,0.002522219,0.5144295,0.001119682,0.003982733,0.002355505,0.001267959,0.00004765893,0.3937646,0.006788531,0.02600605,0.04142486],"study_design_scores_gemma":[0.03928571,0.009040895,0.5073513,0.004760042,0.01306514,0.0004507774,0.003064567,0.001687251,0.2817729,0.00699623,0.1301444,0.002380829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732023,0.004623212,0.0004591581,0.0007928007,0.0002984956,0.0004034546,0.00002236093,0.00008903974,0.02010918],"genre_scores_gemma":[0.9907476,0.0002037248,0.0001780119,0.001248896,0.0001260656,0.00004449848,0.00009492942,0.00002580878,0.007330448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1119916,"threshold_uncertainty_score":0.7504572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009082584351488326,"score_gpt":0.2511803917102642,"score_spread":0.2420978073587759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}