{"id":"W4415178142","doi":"10.2196/preprints.75161","title":"Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial (Preprint)","year":2025,"lang":"en","type":"preprint","venue":"","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cognition; Cognitive training; Cognitive decline; Cholinergic; Population; Randomized controlled trial; Effects of sleep deprivation on cognitive performance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174905,0.00120495,0.001755173,0.0002847027,0.000288354,0.000687493,0.0005444351,0.00163354,0.00447393],"category_scores_gemma":[0.001189003,0.0004620295,0.001291534,0.0002823698,0.0006048316,0.0005906153,0.0003307002,0.001022648,0.0004422301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814134,"about_ca_system_score_gemma":0.0005997482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001840501,"about_ca_topic_score_gemma":0.00260029,"domain_scores_codex":[0.9996322,0.0001680297,0.00004103331,0.00007090982,0.00002758379,0.00006032224],"domain_scores_gemma":[0.9994708,0.0001411511,0.0001675593,0.00004516625,0.00004891989,0.0001264098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9694906,0.01225715,0.001266455,0.0004186575,0.0006832331,0.00001521163,0.00002491221,0.000164639,0.002297674,0.00002814837,0.000286989,0.01306627],"study_design_scores_gemma":[0.8072585,0.1757062,0.0137097,0.00005003064,0.001474382,0.00001867279,0.00002439989,0.0003601897,0.0010042,0.00006557671,0.0003103932,0.00001766689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956873,0.001498917,0.0001525722,0.0001725279,0.0001466669,0.001097943,0.0004862442,0.00003967265,0.0007181192],"genre_scores_gemma":[0.9926879,0.001278056,0.0007882846,0.0004180336,0.0003947833,0.002435463,0.0006605787,0.000007239281,0.001329766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00447393,"threshold_uncertainty_score":0.01496679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05454658277937616,"score_gpt":0.3365900558958241,"score_spread":0.282043473116448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}