{"id":"W4415178242","doi":"10.2196/75161","title":"Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Serious Games","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging","keywords":"Positron emission tomography; Cognitive training; Cognition; Vesicular acetylcholine transporter; Physical exercise; Cardiovascular health; Cognitive decline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001973144,0.001934293,0.002687101,0.0004810209,0.000441063,0.0008377427,0.0007405162,0.002433031,0.003620495],"category_scores_gemma":[0.001992373,0.0006331544,0.001740443,0.0003979903,0.0009382546,0.000816745,0.0004443179,0.00135433,0.000458304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006257279,"about_ca_system_score_gemma":0.0007736226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001541883,"about_ca_topic_score_gemma":0.002285807,"domain_scores_codex":[0.9991199,0.0003976876,0.0001022842,0.0001825582,0.00006613175,0.0001313812],"domain_scores_gemma":[0.9990501,0.0002650211,0.0002632583,0.00008353523,0.00009126901,0.0002469383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9734111,0.01291736,0.001333342,0.00037416,0.0007432968,0.00001943891,0.00002679759,0.0001422875,0.0014102,0.00002522731,0.0001781011,0.00941854],"study_design_scores_gemma":[0.8583673,0.1321391,0.007224275,0.00003362049,0.001170396,0.00001681848,0.00001523695,0.000246811,0.0005145333,0.00006276511,0.0001946217,0.000014516],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939311,0.001957948,0.0002195982,0.0001946289,0.0001724636,0.002236335,0.0004959186,0.00004098995,0.0007510219],"genre_scores_gemma":[0.9907253,0.001299368,0.0008911672,0.0005009413,0.0004608662,0.004347653,0.000652286,0.000007714918,0.001114647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003620495,"threshold_uncertainty_score":0.01211178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469653621088252,"score_gpt":0.3208340348262284,"score_spread":0.3061374986153459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}