{"id":"W4415189438","doi":"10.1101/2025.10.14.681787","title":"Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Israel Science Foundation; United States-Israel Binational Science Foundation; Manitoba Liquor and Lotteries","keywords":"Neural tube; Retinoic acid; Neurulation; Tretinoin; Folic acid; Downregulation and upregulation; Folic acid supplementation; Fetus; Retinol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385427,0.0002551395,0.000231068,0.0002014067,0.0001976145,0.0003032907,0.0002213987,0.0003086378,0.001863859],"category_scores_gemma":[0.0001304176,0.0001225861,0.0002309978,0.0001143024,0.0002426836,0.0001474336,0.0002267969,0.000555052,0.0005632043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004298059,"about_ca_system_score_gemma":0.0003085319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294579,"about_ca_topic_score_gemma":0.001245576,"domain_scores_codex":[0.9998628,0.00001549225,0.00001638732,0.00003951756,0.00004138065,0.00002444427],"domain_scores_gemma":[0.9998752,0.0000149609,0.00004141741,0.00001354955,0.0000151247,0.00003983153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008950988,0.00001259227,0.0002197543,0.00005100591,0.000005782497,0.00004358762,0.00001108352,0.00008229083,0.9972741,0.0001784258,0.0001251182,0.001906658],"study_design_scores_gemma":[0.00001778312,0.00008924888,0.002369881,0.000008183172,0.00001548023,0.00017247,0.00001471223,0.0006776165,0.9904461,0.00004936497,0.006134349,0.000004853014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745918,0.005923011,0.01169034,0.0005357995,0.0001185786,0.00005940317,0.001914783,0.0006772559,0.004488972],"genre_scores_gemma":[0.9871773,0.001319622,0.004162261,0.0001149129,0.00001464794,0.00004784369,0.001156313,0.00006142653,0.005945717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001863859,"threshold_uncertainty_score":0.006235242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020988068697212,"score_gpt":0.2804475141531869,"score_spread":0.2594594454559749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}