{"id":"W4415190942","doi":"10.1007/978-1-0716-4832-2_22","title":"Prioritization of Therapeutic Targets of Inflammation Using Proteomics, Bioinformatics, and In Silico Cell–Cell Interactomics","year":2025,"lang":"en","type":"book-chapter","venue":"Methods in molecular biology","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"","keywords":"In silico; Leukocyte extravasation; Inflammation; Prioritization; Extravasation; Blood–brain barrier; Drug discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006710815,0.001159593,0.001463378,0.001198997,0.0002829619,0.001931284,0.0008047777,0.0006034255,0.006620948],"category_scores_gemma":[0.0007535715,0.0003806674,0.001234826,0.001038197,0.0003023297,0.0007721702,0.0004298466,0.001196492,0.00351855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006111568,"about_ca_system_score_gemma":0.0006143299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006438231,"about_ca_topic_score_gemma":0.001758882,"domain_scores_codex":[0.9997609,0.0000595673,0.00001432413,0.00004915505,0.00009710439,0.00001896079],"domain_scores_gemma":[0.9997092,0.0001847732,0.00002507906,0.00001943951,0.00004700943,0.0000145477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000424469,0.0003177192,0.003507018,0.002318673,0.0004208317,0.0005600458,0.00009893431,0.03698316,0.237756,0.03853427,0.0539607,0.6251182],"study_design_scores_gemma":[0.0001590521,0.0006336814,0.008943497,0.0005737392,0.0007202172,0.002918736,0.0002049718,0.2879693,0.2432616,0.1488383,0.3055867,0.0001901005],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03706083,0.07757787,0.82543,0.005792922,0.001337263,0.000358771,0.004276385,0.004366186,0.04379973],"genre_scores_gemma":[0.1302386,0.05747005,0.7695151,0.002549175,0.0007443348,0.0003231248,0.006032215,0.0007880722,0.03233932],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006620948,"threshold_uncertainty_score":0.02214926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001515831369471,"score_gpt":0.350062164552597,"score_spread":0.3300470062389023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}