{"id":"W4415199256","doi":"10.1093/carcin/bgaf067","title":"Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer","year":2025,"lang":"en","type":"review","venue":"Carcinogenesis","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; London Health Sciences Centre; Western University","funders":"Western University; Institute of Cancer Research; Breast Cancer Society of Canada; Academic Medical Organization of Southwestern Ontario; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Breast cancer; Centrosome; Cancer; Kinase; Biomarker; Downregulation and upregulation; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001344834,0.000570465,0.001083359,0.000239984,0.00006501797,0.00003013879,0.0005351605,0.0007211005,0.0001136675],"category_scores_gemma":[0.00001531832,0.0005121483,0.0006185852,0.0003931064,0.00006896078,0.000002525068,0.0002506494,0.0002122017,0.00003250748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271979,"about_ca_system_score_gemma":0.001222905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003634286,"about_ca_topic_score_gemma":0.0001501476,"domain_scores_codex":[0.9978758,0.00019921,0.0004831305,0.0008236582,0.0001265605,0.0004916959],"domain_scores_gemma":[0.998833,0.00002547677,0.0001713544,0.0007773029,0.0000821889,0.000110679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005380292,0.0001701879,0.001483814,0.01226864,0.0005857234,0.00005786297,0.00002602132,0.000009936507,0.006463427,0.00007205686,0.003364908,0.9754436],"study_design_scores_gemma":[0.0002611378,0.00003626989,0.0001468387,0.002497161,0.0005678685,0.0000604119,0.00001368084,0.000002971105,0.0008323296,0.00001468731,0.9949799,0.0005867773],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009473384,0.9966996,0.00004503013,0.00006169526,0.0004604626,0.0006593182,0.000696059,0.00001569715,0.0004148328],"genre_scores_gemma":[0.0007687791,0.9942842,0.0000460662,0.000714715,0.0003051479,0.0004818527,0.0006855706,0.00008361687,0.002630012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916149,"threshold_uncertainty_score":0.999733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152801163974542,"score_gpt":0.3023043001574912,"score_spread":0.287024183760037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}