{"id":"W4415199256","doi":"10.1093/carcin/bgaf067","title":"Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer","year":2025,"lang":"en","type":"review","venue":"Carcinogenesis","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; London Health Sciences Centre; Western University","funders":"Western University; Institute of Cancer Research; Breast Cancer Society of Canada; Academic Medical Organization of Southwestern Ontario; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Breast cancer; Centrosome; Cancer; Kinase; Biomarker; Downregulation and upregulation; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210015,0.000290593,0.0003139012,0.0004186013,0.0002100477,0.0004442419,0.0002663207,0.0004250843,0.002698597],"category_scores_gemma":[0.0001379734,0.00009278583,0.0002923858,0.0003511638,0.0001731975,0.0003379922,0.0003083484,0.0007389027,0.000734882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432171,"about_ca_system_score_gemma":0.0003801775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002794525,"about_ca_topic_score_gemma":0.0008215796,"domain_scores_codex":[0.9999298,0.00001735646,0.000005170238,0.00001166743,0.00001914197,0.00001683202],"domain_scores_gemma":[0.9999657,0.000005746786,0.000008736267,0.000001823602,0.000008260768,0.000009790241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001880272,0.000666765,0.001569692,0.006138218,0.0001534027,0.001474387,0.000211617,0.001870163,0.212262,0.006629816,0.02297782,0.7441659],"study_design_scores_gemma":[0.0006678102,0.00428388,0.005740664,0.0008702173,0.0004149473,0.0052144,0.0001668453,0.001469995,0.122838,0.002840871,0.8554369,0.00005553675],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05656808,0.9166819,0.003346532,0.004251669,0.001301047,0.0001374692,0.0003236153,0.0001474751,0.01724225],"genre_scores_gemma":[0.2947844,0.6769146,0.004986078,0.001995338,0.0009212646,0.0001301995,0.0005539986,0.00004431352,0.01966975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002698597,"threshold_uncertainty_score":0.009027719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152801163974542,"score_gpt":0.3023043001574912,"score_spread":0.287024183760037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}