{"id":"W4415199614","doi":"10.1093/braincomms/fcaf404","title":"Apolipoprotein E gene allele 4 and amyloid-beta mediate tau-related network breakdown","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Apolipoprotein E; Allele; Gene; Imaging genetics; Pathological; Disease; Neuroimaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004844134,0.0003221446,0.000295544,0.0005204389,0.0001539129,0.0004619378,0.0002929514,0.0002986615,0.001299871],"category_scores_gemma":[0.003321267,0.0002004436,0.0003640233,0.0003895569,0.0003358283,0.0004334993,0.0003431094,0.0002792471,0.0001275118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381175,"about_ca_system_score_gemma":0.000196538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004489179,"about_ca_topic_score_gemma":0.004538249,"domain_scores_codex":[0.9997732,0.00008679463,0.00001445404,0.00006101543,0.00002589236,0.00003872618],"domain_scores_gemma":[0.9989625,0.0005625657,0.0002620777,0.00009095152,0.00004803512,0.00007381568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001994122,0.0001819324,0.8735478,0.0001099996,0.001050836,0.002056264,0.000708345,0.006269514,0.07886923,0.001137605,0.0004730246,0.03360145],"study_design_scores_gemma":[0.00001401156,0.0001196808,0.9903131,0.000005767045,0.0001060911,0.0005112652,0.000102673,0.005859796,0.001849992,0.0009401187,0.0001700497,0.000007543188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997886,0.00022546,0.00144088,0.00004067954,0.000002738909,0.000005848613,0.00007365629,0.00002317835,0.0003016137],"genre_scores_gemma":[0.9992089,0.00007290205,0.0004635874,0.000007247596,0.000005068712,0.000004700753,0.00008385671,0.000004048497,0.0001497409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004489179,"threshold_uncertainty_score":0.008926094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02601459292882551,"score_gpt":0.3304217836677341,"score_spread":0.3044071907389085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}