{"id":"W4415200142","doi":"10.1212/nxi.0000000000200499","title":"Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis","year":2025,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Multiple sclerosis; Intrathecal; Immune system; Disease; Antibody; Genotype; Allele; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005276653,0.0006443746,0.0003363329,0.0007767474,0.0004021634,0.0004162131,0.0003669231,0.0007258097,0.004356482],"category_scores_gemma":[0.001901905,0.0001560515,0.0008439634,0.001169711,0.0003680801,0.0001428742,0.000322443,0.0004915466,0.0002455995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060157,"about_ca_system_score_gemma":0.0003617154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004154103,"about_ca_topic_score_gemma":0.003007085,"domain_scores_codex":[0.999386,0.0001518659,0.00006292092,0.0002479183,0.00008350363,0.00006780069],"domain_scores_gemma":[0.9986317,0.0004698902,0.0006267734,0.00008837569,0.00005500034,0.0001282339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001348003,0.0001157847,0.9713038,0.00009558128,0.001593995,0.002491676,0.0002641118,0.001001432,0.01324609,0.0004442681,0.0003088372,0.007786519],"study_design_scores_gemma":[0.00004131391,0.0001321428,0.9941517,0.0000287697,0.0004616198,0.002591714,0.00005091147,0.0009999303,0.0007208453,0.0003837193,0.0004273511,0.000009943292],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973468,0.0006434973,0.0009026819,0.0001343626,0.00001134257,0.000008179883,0.0004439357,0.00001734455,0.000491999],"genre_scores_gemma":[0.9989454,0.0001250865,0.0005287586,0.00001768639,0.00001539124,0.000006935621,0.0001773589,0.00000448494,0.000178821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004356482,"threshold_uncertainty_score":0.01457387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524138278745751,"score_gpt":0.2808802101617838,"score_spread":0.2456388273743263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}