{"id":"W4415200142","doi":"10.1212/nxi.0000000000200499","title":"Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis","year":2025,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Multiple sclerosis; Intrathecal; Immune system; Disease; Antibody; Genotype; Allele; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004210105,0.0004653798,0.0008160893,0.0006867471,0.0005479312,0.00005874301,0.0003524426,0.0004044262,0.00004305471],"category_scores_gemma":[0.008775448,0.0004570138,0.0001894175,0.0005260828,0.0005119722,0.0001042191,0.0004099795,0.0008279721,0.00007644774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004603875,"about_ca_system_score_gemma":0.0001232248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125673,"about_ca_topic_score_gemma":0.00007899516,"domain_scores_codex":[0.9961853,0.000744726,0.0008497356,0.001136191,0.0002394313,0.000844614],"domain_scores_gemma":[0.9956422,0.002757163,0.0002503965,0.0009120751,0.0002803012,0.0001577948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007099163,0.0002847868,0.1005189,0.0001560037,0.0003863767,0.00004669257,0.0002638819,0.0002299935,0.7812371,0.0002305276,0.00118793,0.1083586],"study_design_scores_gemma":[0.003498008,0.001347129,0.9735016,0.00005611359,0.0002628455,0.00009070684,0.00001899419,0.005243849,0.006395835,0.0001715897,0.00917715,0.0002362286],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809771,0.000311709,0.00156118,0.01321178,0.0005096999,0.002834096,0.00009803061,0.0002619919,0.0002344239],"genre_scores_gemma":[0.9921901,0.001115112,0.001580723,0.00390276,0.0001488434,0.0008501037,0.00001183934,0.00008414626,0.000116374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8729826,"threshold_uncertainty_score":0.9997882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524138278745751,"score_gpt":0.2808802101617838,"score_spread":0.2456388273743263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}