{"id":"W4415200886","doi":"10.1093/noajnl/vdaf226","title":"IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Standards Association; University of Alberta; Alberta Bone and Joint Health Institute; Alberta Cancer Foundation; University of Calgary","funders":"Canadian Institutes of Health Research; University of Calgary","keywords":"Immunosuppression; Evasion (ethics); Glioblastoma; Immune system; Therapeutic approach; Tumor cells; Immunotherapy; Immune surveillance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415467,0.0003092277,0.0001891724,0.0002172014,0.0001060908,0.0003328009,0.0001209677,0.0001445613,0.001411109],"category_scores_gemma":[0.0000908004,0.00006294469,0.0002020922,0.0001074459,0.0001589607,0.0001099531,0.0002283723,0.0003551468,0.0003892393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667709,"about_ca_system_score_gemma":0.0003217459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009012372,"about_ca_topic_score_gemma":0.002428994,"domain_scores_codex":[0.9998857,0.00001389321,0.000008676702,0.00001609508,0.00004497057,0.00003073539],"domain_scores_gemma":[0.9999038,0.000009553961,0.00002723192,0.000009860904,0.00001752097,0.00003206468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172579,0.00004574054,0.001136013,0.00007685702,0.00001233085,0.00005400166,0.000008239553,0.00008891634,0.994548,0.0001033128,0.0002699386,0.003483961],"study_design_scores_gemma":[0.00003602549,0.0005736691,0.02877509,0.00002278129,0.00004656801,0.0003240725,0.00006393686,0.00153723,0.9608081,0.0001143339,0.00768842,0.000009687375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865854,0.004355836,0.003435706,0.000274123,0.00008381828,0.00002886699,0.001602118,0.0002115511,0.003422621],"genre_scores_gemma":[0.9956855,0.0009298566,0.0009095279,0.00008219933,0.00001916308,0.00002541729,0.0007526468,0.0000213863,0.001574335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411109,"threshold_uncertainty_score":0.004720628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004226908003913286,"score_gpt":0.2461605308378314,"score_spread":0.2419336228339181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}