{"id":"W4415209196","doi":"10.1161/circresaha.125.327050","title":"SCarP: Proteome Heterogeneity Characterization of Primary Mouse Cardiomyocytes","year":2025,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bruker (Canada)","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Proteome; Primary (astronomy); Primary cell; Cell; Myocyte; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004346239,0.0002423321,0.0004441258,0.0003945116,0.0002138775,0.00007334555,0.0005369297,0.0009051874,0.0001441007],"category_scores_gemma":[0.00009264983,0.0002722667,0.0001922724,0.0005234348,0.0001951274,0.0001305897,0.0002517875,0.001776195,0.00001567707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004391411,"about_ca_system_score_gemma":0.0003148064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004722631,"about_ca_topic_score_gemma":7.115397e-7,"domain_scores_codex":[0.9974705,0.0001169506,0.0005277323,0.0006216543,0.0008469697,0.0004162208],"domain_scores_gemma":[0.9975749,0.0001435972,0.0002828582,0.001126725,0.0008246613,0.00004723917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001415174,0.0000367878,0.00118087,0.002141957,0.00006809783,0.00000598484,0.00002243264,0.00003962158,0.9600557,0.0001057005,0.03489455,0.001434156],"study_design_scores_gemma":[0.0002102077,0.00001053561,0.0007776858,0.0002861587,0.00002798935,0.000003555928,0.000003453611,0.0003007821,0.7092271,0.0009008985,0.2879201,0.0003316021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6545413,0.0004996124,0.07762045,0.2037849,0.0002064645,0.009000059,0.004520372,0.00140187,0.04842488],"genre_scores_gemma":[0.6309969,0.002191629,0.02344203,0.09983622,0.01673423,0.02499559,0.1080561,0.001090842,0.0926564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2530255,"threshold_uncertainty_score":0.9999729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06128939017812548,"score_gpt":0.3482352971334444,"score_spread":0.286945906955319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}