{"id":"W4415215053","doi":"10.20944/preprints202510.1182.v1","title":"M1 Macrophages are a Source of IL-1α: A Driver of Progesterone Metabolism and Myometrial Contraction","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Intracellular; Contractility; Contraction (grammar); Metabolism; Inflammation; Monocyte; Uterine contraction; Blockade; Uterus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731112,0.0005165896,0.0003871178,0.000423888,0.0004383704,0.0005657487,0.000220223,0.0005814662,0.001872678],"category_scores_gemma":[0.0002176202,0.0002294791,0.0004061213,0.0002155296,0.0003340948,0.0002778762,0.0004525755,0.0008060618,0.001040774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006829,"about_ca_system_score_gemma":0.0002766296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004522495,"about_ca_topic_score_gemma":0.0005412024,"domain_scores_codex":[0.9996902,0.00006670673,0.00002042473,0.00006302224,0.00005104865,0.0001087592],"domain_scores_gemma":[0.9998507,0.00001308474,0.00004495428,0.00001499671,0.00003229273,0.00004392649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006961268,0.0001033114,0.004541504,0.0004180306,0.0000190082,0.0005629789,0.0002380667,0.00005083178,0.9838854,0.0004895404,0.0005118922,0.008483364],"study_design_scores_gemma":[0.0002599265,0.002880822,0.1244315,0.0002897316,0.0001895574,0.005244663,0.001520754,0.001143626,0.7946327,0.001364889,0.06800067,0.00004106219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9307367,0.05298873,0.006281148,0.001733221,0.0003352235,0.0002510129,0.001123596,0.0001838179,0.006366514],"genre_scores_gemma":[0.9761994,0.01229339,0.002862629,0.0005315712,0.0002805161,0.0002163495,0.0006536546,0.00002548273,0.006936878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872678,"threshold_uncertainty_score":0.006264746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05769455490410566,"score_gpt":0.3130964458460231,"score_spread":0.2554018909419175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}